Jawing about TNF: New Hope for Cherubism

Deborah Veis Novack; Roberta Faccio

doi:10.1016/j.cell.2006.12.019

Jawing about TNF: New Hope for Cherubism

Deborah Veis Novack, Roberta Faccio

Research output: Contribution to journal › Short survey › peer-review

31 Scopus citations

Abstract

Mutations in the SH3-domain binding protein 2 (SH3BP2) are known to cause a rare childhood disorder called cherubism that is characterized by inflammation and bone loss in the jaw, but the mechanism has remained unclear. In this issue, Ueki et al. (Ueki et al., 2007) now demonstrate that a cherubism mutation activates mouse Sh3bp2 resulting in enhanced production of the cytokine TNF-α by myeloid cells, leading to both bone loss and inflammation.

Original language	English
Pages (from-to)	15-17
Number of pages	3
Journal	Cell
Volume	128
Issue number	1
DOIs	https://doi.org/10.1016/j.cell.2006.12.019
State	Published - Jan 12 2007

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title = "Jawing about TNF: New Hope for Cherubism",

abstract = "Mutations in the SH3-domain binding protein 2 (SH3BP2) are known to cause a rare childhood disorder called cherubism that is characterized by inflammation and bone loss in the jaw, but the mechanism has remained unclear. In this issue, Ueki et al. (Ueki et al., 2007) now demonstrate that a cherubism mutation activates mouse Sh3bp2 resulting in enhanced production of the cytokine TNF-α by myeloid cells, leading to both bone loss and inflammation.",

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N2 - Mutations in the SH3-domain binding protein 2 (SH3BP2) are known to cause a rare childhood disorder called cherubism that is characterized by inflammation and bone loss in the jaw, but the mechanism has remained unclear. In this issue, Ueki et al. (Ueki et al., 2007) now demonstrate that a cherubism mutation activates mouse Sh3bp2 resulting in enhanced production of the cytokine TNF-α by myeloid cells, leading to both bone loss and inflammation.

AB - Mutations in the SH3-domain binding protein 2 (SH3BP2) are known to cause a rare childhood disorder called cherubism that is characterized by inflammation and bone loss in the jaw, but the mechanism has remained unclear. In this issue, Ueki et al. (Ueki et al., 2007) now demonstrate that a cherubism mutation activates mouse Sh3bp2 resulting in enhanced production of the cytokine TNF-α by myeloid cells, leading to both bone loss and inflammation.

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Jawing about TNF: New Hope for Cherubism

Abstract

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