Jack of all trades, master of each: The diversity of fibroblast growth factor signalling in eye development

Neoklis Makrides, Qian Wang, Chenqi Tao, Samuel Schwartz, Xin Zhang

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

A central question in development biology is how a limited set of signalling pathways can instruct unlimited diversity of multicellular organisms. In this review, we use three ocular tissues as models of increasing complexity to present the astounding versatility of fibroblast growth factor (FGF) signalling. In the lacrimal gland, we highlight the specificity of FGF signalling in a one-dimensional model of budding morphogenesis. In the lens, we showcase the dynamics of FGF signalling in altering functional outcomes in a two-dimensional space. In the retina, we present the prolific utilization of FGF signalling from three-dimensional development to homeostasis. These examples not only shed light on the cellular basis for the perfection and complexity of ocular development, but also serve as paradigms for the diversity of FGF signalling.

Original languageEnglish
Article number210265
JournalOpen Biology
Volume12
Issue number1
DOIs
StatePublished - Jan 12 2022

Keywords

  • ciliary margin
  • FGF
  • lacrimal gland
  • lens
  • optic cup
  • retina

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