IVUS-based computational modeling and planar biaxial artery material properties for human coronary plaque vulnerability assessment

Haofei Liu, Mingchao Cai, Chun Yang, Jie Zheng, Richard Bach, Mehmet H. Kural, Kristen L. Billiar, David Muccigrosso, Dongsi Lu, Dalin Tang

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Image-based computational modeling has been introduced for vulnerable atherosclerotic plaques to identify critical mechanical conditions which may be used for better plaque assessment and rupture predictions. In vivo patientspecific coronary plaque models are lagging due to limitations on non-invasive image resolution, flow data, and vessel material properties. A framework is proposed to combine intravascular ultrasound (IVUS) imaging, biaxial mechanical testing and computational modeling with fluid-structure interactions and anisotropic material properties to acquire better and more complete plaque data and make more accurate plaque vulnerability assessment and predictions. Impact of pre-shrinkstretch process, vessel curvature and high blood pressure on stress, strain, flow velocity and flow maximum principal shear stress was investigated.

Original languageEnglish
Pages (from-to)77-93
Number of pages17
JournalMCB Molecular and Cellular Biomechanics
Volume9
Issue number1
StatePublished - May 14 2012

Keywords

  • Atherosclerotic plaque rupture
  • Cardiovascular
  • Coronary artery
  • Fluid-structure interaction
  • IVUS

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