TY - JOUR
T1 - iTBS to Relieve Depression and Executive Dysfunction in Older Adults
T2 - An Open Label Study
AU - Cristancho, Pilar
AU - Kamel, Lojine
AU - Araque, Manuela
AU - Berger, Jacinda
AU - Blumberger, Daniel M.
AU - Miller, J. Philip
AU - Barch, Deanna M.
AU - Lenze, Eric J.
N1 - Funding Information:
Research reported in this publication was supported by the National Center for Advancing Translational Sciences of the National Institutes of Health KL2TR002346 to Washington University, The Center for Brain Research in Mood Disorders at Washington University and the Foundation for Barnes Jewish Hospital.
Publisher Copyright:
© 2020 American Association for Geriatric Psychiatry
PY - 2020/11
Y1 - 2020/11
N2 - Background: Executive Function Deficits (EFD) accompany depression and are associated with poor outcomes in older adults. We examined whether Intermittent Theta Burst Stimulation (iTBS) could improve depression with EFD. Methods: Thirteen geriatric patients with depression and EFD were enrolled. Open label iTBS was delivered bilaterally over the dorso-lateral-prefrontal-cortex for four weeks. Results: Montgomery Asberg Depression Scale scores improved significantly from baseline to treatment-end, mean change in score = 11.82 points, 95% CI = 8.3, 15.4. The Flanker Inhibitory control and attention test showed significant improvement in executive function from baseline to treatment-end, mean change in score = −7.73, 95% CI ( −13.54, −1.92). Side effects included twitching in facial muscles (n = 11), headaches (n = 10) and stimulation discomfort (n = 4). Limitations: Small sample size and lack of a sham comparator. Conclusion: iTBS improved depression with EFD in older adults. Side effects appeared higher than in previous iTBS studies.
AB - Background: Executive Function Deficits (EFD) accompany depression and are associated with poor outcomes in older adults. We examined whether Intermittent Theta Burst Stimulation (iTBS) could improve depression with EFD. Methods: Thirteen geriatric patients with depression and EFD were enrolled. Open label iTBS was delivered bilaterally over the dorso-lateral-prefrontal-cortex for four weeks. Results: Montgomery Asberg Depression Scale scores improved significantly from baseline to treatment-end, mean change in score = 11.82 points, 95% CI = 8.3, 15.4. The Flanker Inhibitory control and attention test showed significant improvement in executive function from baseline to treatment-end, mean change in score = −7.73, 95% CI ( −13.54, −1.92). Side effects included twitching in facial muscles (n = 11), headaches (n = 10) and stimulation discomfort (n = 4). Limitations: Small sample size and lack of a sham comparator. Conclusion: iTBS improved depression with EFD in older adults. Side effects appeared higher than in previous iTBS studies.
KW - Depression
KW - executive dysfunction
KW - executive function
KW - intermittent theta burst stimulation
KW - late life depression
KW - neuromodulation
KW - older adults
KW - transcranial magnetic stimulation
UR - http://www.scopus.com/inward/record.url?scp=85082804728&partnerID=8YFLogxK
U2 - 10.1016/j.jagp.2020.03.001
DO - 10.1016/j.jagp.2020.03.001
M3 - Article
C2 - 32268978
AN - SCOPUS:85082804728
SN - 1064-7481
VL - 28
SP - 1195
EP - 1199
JO - American Journal of Geriatric Psychiatry
JF - American Journal of Geriatric Psychiatry
IS - 11
ER -