TY - JOUR
T1 - iTBS to Relieve Depression and Executive Dysfunction in Older Adults
T2 - An Open Label Study
AU - Cristancho, Pilar
AU - Kamel, Lojine
AU - Araque, Manuela
AU - Berger, Jacinda
AU - Blumberger, Daniel M.
AU - Miller, J. Philip
AU - Barch, Deanna M.
AU - Lenze, Eric J.
N1 - Publisher Copyright:
© 2020 American Association for Geriatric Psychiatry
PY - 2020/11
Y1 - 2020/11
N2 - Background: Executive Function Deficits (EFD) accompany depression and are associated with poor outcomes in older adults. We examined whether Intermittent Theta Burst Stimulation (iTBS) could improve depression with EFD. Methods: Thirteen geriatric patients with depression and EFD were enrolled. Open label iTBS was delivered bilaterally over the dorso-lateral-prefrontal-cortex for four weeks. Results: Montgomery Asberg Depression Scale scores improved significantly from baseline to treatment-end, mean change in score = 11.82 points, 95% CI = 8.3, 15.4. The Flanker Inhibitory control and attention test showed significant improvement in executive function from baseline to treatment-end, mean change in score = −7.73, 95% CI ( −13.54, −1.92). Side effects included twitching in facial muscles (n = 11), headaches (n = 10) and stimulation discomfort (n = 4). Limitations: Small sample size and lack of a sham comparator. Conclusion: iTBS improved depression with EFD in older adults. Side effects appeared higher than in previous iTBS studies.
AB - Background: Executive Function Deficits (EFD) accompany depression and are associated with poor outcomes in older adults. We examined whether Intermittent Theta Burst Stimulation (iTBS) could improve depression with EFD. Methods: Thirteen geriatric patients with depression and EFD were enrolled. Open label iTBS was delivered bilaterally over the dorso-lateral-prefrontal-cortex for four weeks. Results: Montgomery Asberg Depression Scale scores improved significantly from baseline to treatment-end, mean change in score = 11.82 points, 95% CI = 8.3, 15.4. The Flanker Inhibitory control and attention test showed significant improvement in executive function from baseline to treatment-end, mean change in score = −7.73, 95% CI ( −13.54, −1.92). Side effects included twitching in facial muscles (n = 11), headaches (n = 10) and stimulation discomfort (n = 4). Limitations: Small sample size and lack of a sham comparator. Conclusion: iTBS improved depression with EFD in older adults. Side effects appeared higher than in previous iTBS studies.
KW - Depression
KW - executive dysfunction
KW - executive function
KW - intermittent theta burst stimulation
KW - late life depression
KW - neuromodulation
KW - older adults
KW - transcranial magnetic stimulation
UR - http://www.scopus.com/inward/record.url?scp=85082804728&partnerID=8YFLogxK
U2 - 10.1016/j.jagp.2020.03.001
DO - 10.1016/j.jagp.2020.03.001
M3 - Article
C2 - 32268978
AN - SCOPUS:85082804728
SN - 1064-7481
VL - 28
SP - 1195
EP - 1199
JO - American Journal of Geriatric Psychiatry
JF - American Journal of Geriatric Psychiatry
IS - 11
ER -