Isotope derivative measurements of plasma norepinephrine and epinephrine in man

P. E. Cryer

Research output: Contribution to journalReview articlepeer-review

132 Scopus citations


Enzymatic isotope derivative methods have provided a sensitive tool for the measurement of norepinephrine and epinephrine in plasma and tissues and, therefore, for the study of adrenergic physiology and pathophysiology in man. In contrast to adrenergic physiology, which has an extensive data base derived with earlier methods, human adrenergic pathophysiology, aside from the extremes of catecholamine excess and deficit, has been largely unexplored because of the limitations of those methods. Although the application of isotope derivative methodology has already permitted some new insights into possible involvement of the adrenergic nervous system in a variety of human diseases, it seems likely that this exploration has only begun.

Original languageEnglish
Pages (from-to)1071-1082
Number of pages12
Issue number11
StatePublished - Jan 1 1976


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