Isoquinolines as antagonists of the P2X₇ nucleotide receptor: High selectivity for the human versus rat receptor homologues

Keyphrases

• High Selectivity 100%
• Nucleotide Receptors 100%
• P2X7 Receptor (P2X7R) 100%
• Isoquinoline 100%
• KN-62 33%
• Ethidium 16%
• Trifluoromethylphenylpiperazine (TFMPP) 16%
• Recombinant 8%
• Amino Acids 8%
• Receptor Function 8%
• Lymphocytes 8%
• Ca2+ Influx 8%
• Ethyl 8%
• Amino 8%
• Functional Response 8%
• Human Lymphocytes 8%
• Molecular Identity 8%
• Human Embryonic Kidney Cells 8%
• Structural Domains 8%
• Cation Channel 8%
• THP1 8%
• N-methylation 8%
• Benzyl 8%
• P2X Receptors 8%
• Quinolinesulfonamides 8%
• Functional Traits 8%
• Organic Dyes 8%
• Tyrosyl 8%
• Large Extracellular Loop 8%
• Pore Activation 8%
• Cation Uptake 8%
• Cation Current 8%
• Pore Channel 8%
• Human Embryonic Kidney 293 (HEK293) 8%
• Amino Acid Identity 8%
• Leukocyte Cells 8%

Pharmacology, Toxicology and Pharmaceutical Science

• Receptor 100%
• Isoquinoline Derivative 100%
• Rat 100%
• Adenosine Triphosphate 60%
• Purinergic P2X7 Receptor 60%
• Amino Acid 40%
• Ethidium 40%
• Cation Channel 20%
• Calcium Ion 20%
• Sulfonamide 20%
• Isoquinoline 20%
• Purinergic P2X Receptor 20%
• Messenger RNA 20%
• Cation 20%

Neuroscience

• Isoquinoline 100%
• Receptor 100%
• Adenosine Triphosphate 75%
• Purinergic P2X7 Receptor 75%
• Amino Acid 50%
• Lymphocyte 50%
• Leukocyte 25%
• Cation Channel 25%
• Cell Line 25%
• Amino Terminal Sequence 25%
• Purinergic P2X Receptor 25%
• Sulfonamide 25%
• Messenger RNA 25%