Isoprenoid Metabolism in Apicomplexan Parasites

Leah Imlay; Audrey R. Odom

doi:10.1007/s40588-014-0006-7

Isoprenoid Metabolism in Apicomplexan Parasites

Leah Imlay, Audrey R. Odom

Division of Infectious Disease

Research output: Contribution to journal › Review article › peer-review

53 Scopus citations

Abstract

Apicomplexan parasites include some of the most prevalent and deadly human pathogens. Novel antiparasitic drugs are urgently needed. Synthesis and metabolism of isoprenoids may present multiple targets for therapeutic intervention. The apicoplast-localized methylerythritol phosphate pathway for isoprenoid precursor biosynthesis is distinct from the mevalonate pathway used by the mammalian host, and this pathway is apparently essential in most Apicomplexa. In this review, we discuss the current field of research on production and metabolic fates of isoprenoids in apicomplexan parasites, including the acquisition of host isoprenoid precursors and downstream products. We describe recent work identifying the first methylerythritol phosphate pathway regulator in apicomplexan parasites, and introduce several promising areas for ongoing research into this well-validated antiparasitic target.

Original language	English
Pages (from-to)	37-50
Number of pages	14
Journal	Current Clinical Microbiology Reports
Volume	1
Issue number	3-4
DOIs	https://doi.org/10.1007/s40588-014-0006-7
State	Published - Dec 1 2014

Keywords

Apicomplexa
Fosmidomycin
Isoprenoid
Metabolism
Methylerythritol phosphate (MEP) pathway
Plasmodium

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10.1007/s40588-014-0006-7

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title = "Isoprenoid Metabolism in Apicomplexan Parasites",

abstract = "Apicomplexan parasites include some of the most prevalent and deadly human pathogens. Novel antiparasitic drugs are urgently needed. Synthesis and metabolism of isoprenoids may present multiple targets for therapeutic intervention. The apicoplast-localized methylerythritol phosphate pathway for isoprenoid precursor biosynthesis is distinct from the mevalonate pathway used by the mammalian host, and this pathway is apparently essential in most Apicomplexa. In this review, we discuss the current field of research on production and metabolic fates of isoprenoids in apicomplexan parasites, including the acquisition of host isoprenoid precursors and downstream products. We describe recent work identifying the first methylerythritol phosphate pathway regulator in apicomplexan parasites, and introduce several promising areas for ongoing research into this well-validated antiparasitic target.",

keywords = "Apicomplexa, Fosmidomycin, Isoprenoid, Metabolism, Methylerythritol phosphate (MEP) pathway, Plasmodium",

author = "Leah Imlay and Odom, {Audrey R.}",

note = "Funding Information: Dr. Odom is supported by the Children{\textquoteright}s Discovery Institute of Washington University and St. Louis Children{\textquoteright}s Hospital (MD-LI-2011-171), NIH/NIAID R01AI103280, a March of Dimes Basil O{\textquoteright}Connor Starter Scholar Research Award), and a Doris Duke Charitable Foundation Clinical Scientist Development award. LI is supported by an NIH/NIGMS Training grant (T32-AI007172). Publisher Copyright: {\textcopyright} 2014, Springer International Publishing AG.",

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doi = "10.1007/s40588-014-0006-7",

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AU - Odom, Audrey R.

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PY - 2014/12/1

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N2 - Apicomplexan parasites include some of the most prevalent and deadly human pathogens. Novel antiparasitic drugs are urgently needed. Synthesis and metabolism of isoprenoids may present multiple targets for therapeutic intervention. The apicoplast-localized methylerythritol phosphate pathway for isoprenoid precursor biosynthesis is distinct from the mevalonate pathway used by the mammalian host, and this pathway is apparently essential in most Apicomplexa. In this review, we discuss the current field of research on production and metabolic fates of isoprenoids in apicomplexan parasites, including the acquisition of host isoprenoid precursors and downstream products. We describe recent work identifying the first methylerythritol phosphate pathway regulator in apicomplexan parasites, and introduce several promising areas for ongoing research into this well-validated antiparasitic target.

AB - Apicomplexan parasites include some of the most prevalent and deadly human pathogens. Novel antiparasitic drugs are urgently needed. Synthesis and metabolism of isoprenoids may present multiple targets for therapeutic intervention. The apicoplast-localized methylerythritol phosphate pathway for isoprenoid precursor biosynthesis is distinct from the mevalonate pathway used by the mammalian host, and this pathway is apparently essential in most Apicomplexa. In this review, we discuss the current field of research on production and metabolic fates of isoprenoids in apicomplexan parasites, including the acquisition of host isoprenoid precursors and downstream products. We describe recent work identifying the first methylerythritol phosphate pathway regulator in apicomplexan parasites, and introduce several promising areas for ongoing research into this well-validated antiparasitic target.

KW - Apicomplexa

KW - Fosmidomycin

KW - Isoprenoid

KW - Metabolism

KW - Methylerythritol phosphate (MEP) pathway

KW - Plasmodium

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DO - 10.1007/s40588-014-0006-7

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AN - SCOPUS:84995910092

SN - 2196-5471

VL - 1

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EP - 50

JO - Current Clinical Microbiology Reports

JF - Current Clinical Microbiology Reports

IS - 3-4

ER -

Isoprenoid Metabolism in Apicomplexan Parasites

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