Isometric contractile function following nerve grafting: A study of graft storage

Peter J. Evans, David C. Awerbuck, Susan E. Mackinnon, Judith A. Wade, Nancy H. McKee

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

In order to assess the effects of storage on nerve grafts, the isometric contractile function of the gastrocnemius muscle was assessed 14 months following sciatic nerve autografting in the rat. Three‐centimeter sciatic nerve grafts were stored at either 5°C or 22°C for 6 h, 24 h, or 3 weeks in an organ transplant solution. Muscle mass and maximal force in the fresh control graft group returned to 47% and 36% of normal levels, respectively, which was similar to stored grafts. Storage at 5°C was superior to 22°C and there was no decrement in contractile function in grafts stored up to 3 weeks at 5°C. These findings suggest that the storage of nerve grafts is a feasible technique that might be applied to nerve allografts, thus permitting elective reconstruction of large peripheral nerve gaps. © 1994 John Wiley & Sons, Inc.

Original languageEnglish
Pages (from-to)1190-1200
Number of pages11
JournalMuscle & Nerve
Volume17
Issue number10
DOIs
StatePublished - Oct 1994

Keywords

  • gastrocnemius muscle
  • graft storage
  • muscle function
  • nerve grafting
  • transplantation

Fingerprint Dive into the research topics of 'Isometric contractile function following nerve grafting: A study of graft storage'. Together they form a unique fingerprint.

  • Cite this