Abstract
The Aloe protein of 14 kDa from the Aloe vera leaf gel was isolated by an ion exchange chromatography using DEAE-cellulose and CM-cellulose column. The purified Aloe protein exhibited a potent anti-fungal activity against Candida paraprilosis, Candida krusei and Candida albicans. In addition, the purified Aloe protein also showed an anti-inflammatory property against pure lipoxygenase and cyclooxygenase-2 with 84% and 73% inhibition, respectively, and was verified by binding with these proteins by real time method by the phenomenon of surface plasmon resonance. This Aloe protein is a novel protein possessing antifungal and anti-inflammatory properties and thus sets a platform to be used as a medicinal plant product.
Original language | English |
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Pages (from-to) | 38-43 |
Number of pages | 6 |
Journal | International Journal of Biological Macromolecules |
Volume | 48 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1 2011 |
Keywords
- Aloe vera
- Anti-fungal
- Hemagglutination
- Inflammation
- Surface plasmon resonance