TY - JOUR
T1 - Isolation and characterization of isoprothrombin in the rat
AU - Morrissey, Jeremiah J.
AU - Jones, John P.
AU - Olson, Robert E.
PY - 1973/10/1
Y1 - 1973/10/1
N2 - Isoprothrombin, a protein antigenically related to prothrombin, which accumulates in the hepatic endoplasmic reticulum of vitamin K-deficient or warfarin-treated rats, has been isolated by affinity chromatography employing rat prothrombin antibodies linked to Sepharose. Isoprothrombin has the same molecular weight as prothrombin but a different mobility on disc gel electrophoresis, is not barium adsorbable nor activatable to thrombin by factor Xa. Isoprothrombin is converted to thrombin by Echis carinatus venom through the same intermediates as prothrombin.
AB - Isoprothrombin, a protein antigenically related to prothrombin, which accumulates in the hepatic endoplasmic reticulum of vitamin K-deficient or warfarin-treated rats, has been isolated by affinity chromatography employing rat prothrombin antibodies linked to Sepharose. Isoprothrombin has the same molecular weight as prothrombin but a different mobility on disc gel electrophoresis, is not barium adsorbable nor activatable to thrombin by factor Xa. Isoprothrombin is converted to thrombin by Echis carinatus venom through the same intermediates as prothrombin.
UR - https://www.scopus.com/pages/publications/0015842506
U2 - 10.1016/0006-291X(73)90803-6
DO - 10.1016/0006-291X(73)90803-6
M3 - Article
C2 - 4127712
AN - SCOPUS:0015842506
SN - 0006-291X
VL - 54
SP - 1075
EP - 1082
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -