Ischemic post-conditioning attenuates acute lung injury induced by intestinal ischemia-reperfusion in mice: Role of Nrf2

Qing Tao Meng; Chen Cao; Yang Wu; Hui Min Liu; Wei Li; Qian Sun; Rong Chen; Yong Guang Xiao; Ling Hua Tang; Ying Jiang; Yan Leng; Shao Qing Lei; Chris C. Lee; Devin M. Barry; Xiangdong Chen; Zhong Yuan Xia

doi:10.1038/labinvest.2016.87

Ischemic post-conditioning attenuates acute lung injury induced by intestinal ischemia-reperfusion in mice: Role of Nrf2

Qing Tao Meng, Chen Cao, Yang Wu, Hui Min Liu, Wei Li, Qian Sun, Rong Chen, Yong Guang Xiao, Ling Hua Tang, Ying Jiang, Yan Leng, Shao Qing Lei, Chris C. Lee, Devin M. Barry, Xiangdong Chen, Zhong Yuan Xia

Division of General Anesthesia

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Intestinal ischemic post-conditioning (IPo) protects against lung injury induced by intestinal ischemia-reperfusion (IIR) partly through promotion of expression and function of heme oxygenase-1 (HO-1). NF-E2-related factor-2 (Nrf2) is a key transcription factor that interacts with HO-1 and regulates antioxidant defense. However, the role of Nrf2 in IPo protection of IIR-induced pulmonary injury is not completely understood. Here we show that IPo significantly attenuated IIR-induced lung injury and suppressed oxidative stress and systemic inflammatory responses. IPo also increased the expression of both Nrf2 and HO-1. Consistently, the beneficial effects of IPo were abolished by ATRA and Brusatol, potent inhibitors of Nrf2. Moreover, the Nrf2 agonist t-BHQ showed similar activity as IPo. Taken together, our data suggest that Nrf2 activity, along with HO-1, plays an important role in the protective effects of IPo against IIR-induced acute lung injury.

Original language	English
Pages (from-to)	1087-1104
Number of pages	18
Journal	Laboratory Investigation
Volume	96
Issue number	10
DOIs	https://doi.org/10.1038/labinvest.2016.87
State	Published - Oct 1 2016

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Meng, Q. T., Cao, C., Wu, Y., Liu, H. M., Li, W., Sun, Q., Chen, R., Xiao, Y. G., Tang, L. H., Jiang, Y., Leng, Y., Lei, S. Q., Lee, C. C., Barry, D. M., Chen, X., & Xia, Z. Y. (2016). Ischemic post-conditioning attenuates acute lung injury induced by intestinal ischemia-reperfusion in mice: Role of Nrf2. Laboratory Investigation, 96(10), 1087-1104. https://doi.org/10.1038/labinvest.2016.87

@article{772760dd326f46a9b479363296040db4,

title = "Ischemic post-conditioning attenuates acute lung injury induced by intestinal ischemia-reperfusion in mice: Role of Nrf2",

abstract = "Intestinal ischemic post-conditioning (IPo) protects against lung injury induced by intestinal ischemia-reperfusion (IIR) partly through promotion of expression and function of heme oxygenase-1 (HO-1). NF-E2-related factor-2 (Nrf2) is a key transcription factor that interacts with HO-1 and regulates antioxidant defense. However, the role of Nrf2 in IPo protection of IIR-induced pulmonary injury is not completely understood. Here we show that IPo significantly attenuated IIR-induced lung injury and suppressed oxidative stress and systemic inflammatory responses. IPo also increased the expression of both Nrf2 and HO-1. Consistently, the beneficial effects of IPo were abolished by ATRA and Brusatol, potent inhibitors of Nrf2. Moreover, the Nrf2 agonist t-BHQ showed similar activity as IPo. Taken together, our data suggest that Nrf2 activity, along with HO-1, plays an important role in the protective effects of IPo against IIR-induced acute lung injury.",

author = "Meng, {Qing Tao} and Chen Cao and Yang Wu and Liu, {Hui Min} and Wei Li and Qian Sun and Rong Chen and Xiao, {Yong Guang} and Tang, {Ling Hua} and Ying Jiang and Yan Leng and Lei, {Shao Qing} and Lee, {Chris C.} and Barry, {Devin M.} and Xiangdong Chen and Xia, {Zhong Yuan}",

note = "Publisher Copyright: {\textcopyright} 2016 USCAP, Inc.",

year = "2016",

month = oct,

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doi = "10.1038/labinvest.2016.87",

language = "English",

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Meng, QT, Cao, C, Wu, Y, Liu, HM, Li, W, Sun, Q, Chen, R, Xiao, YG, Tang, LH, Jiang, Y, Leng, Y, Lei, SQ, Lee, CC, Barry, DM, Chen, X & Xia, ZY 2016, 'Ischemic post-conditioning attenuates acute lung injury induced by intestinal ischemia-reperfusion in mice: Role of Nrf2', Laboratory Investigation, vol. 96, no. 10, pp. 1087-1104. https://doi.org/10.1038/labinvest.2016.87

TY - JOUR

T1 - Ischemic post-conditioning attenuates acute lung injury induced by intestinal ischemia-reperfusion in mice

T2 - Role of Nrf2

AU - Meng, Qing Tao

AU - Cao, Chen

AU - Wu, Yang

AU - Liu, Hui Min

AU - Li, Wei

AU - Sun, Qian

AU - Chen, Rong

AU - Xiao, Yong Guang

AU - Tang, Ling Hua

AU - Jiang, Ying

AU - Leng, Yan

AU - Lei, Shao Qing

AU - Lee, Chris C.

AU - Barry, Devin M.

AU - Chen, Xiangdong

AU - Xia, Zhong Yuan

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Intestinal ischemic post-conditioning (IPo) protects against lung injury induced by intestinal ischemia-reperfusion (IIR) partly through promotion of expression and function of heme oxygenase-1 (HO-1). NF-E2-related factor-2 (Nrf2) is a key transcription factor that interacts with HO-1 and regulates antioxidant defense. However, the role of Nrf2 in IPo protection of IIR-induced pulmonary injury is not completely understood. Here we show that IPo significantly attenuated IIR-induced lung injury and suppressed oxidative stress and systemic inflammatory responses. IPo also increased the expression of both Nrf2 and HO-1. Consistently, the beneficial effects of IPo were abolished by ATRA and Brusatol, potent inhibitors of Nrf2. Moreover, the Nrf2 agonist t-BHQ showed similar activity as IPo. Taken together, our data suggest that Nrf2 activity, along with HO-1, plays an important role in the protective effects of IPo against IIR-induced acute lung injury.

AB - Intestinal ischemic post-conditioning (IPo) protects against lung injury induced by intestinal ischemia-reperfusion (IIR) partly through promotion of expression and function of heme oxygenase-1 (HO-1). NF-E2-related factor-2 (Nrf2) is a key transcription factor that interacts with HO-1 and regulates antioxidant defense. However, the role of Nrf2 in IPo protection of IIR-induced pulmonary injury is not completely understood. Here we show that IPo significantly attenuated IIR-induced lung injury and suppressed oxidative stress and systemic inflammatory responses. IPo also increased the expression of both Nrf2 and HO-1. Consistently, the beneficial effects of IPo were abolished by ATRA and Brusatol, potent inhibitors of Nrf2. Moreover, the Nrf2 agonist t-BHQ showed similar activity as IPo. Taken together, our data suggest that Nrf2 activity, along with HO-1, plays an important role in the protective effects of IPo against IIR-induced acute lung injury.

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SN - 0023-6837

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SP - 1087

EP - 1104

JO - Laboratory Investigation

JF - Laboratory Investigation

IS - 10

ER -

Ischemic post-conditioning attenuates acute lung injury induced by intestinal ischemia-reperfusion in mice: Role of Nrf2

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