Ischemic post-conditioning attenuates acute lung injury induced by intestinal ischemia-reperfusion in mice: Role of Nrf2

Qing Tao Meng, Chen Cao, Yang Wu, Hui Min Liu, Wei Li, Qian Sun, Rong Chen, Yong Guang Xiao, Ling Hua Tang, Ying Jiang, Yan Leng, Shao Qing Lei, Chris C. Lee, Devin M. Barry, Xiangdong Chen, Zhong Yuan Xia

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Intestinal ischemic post-conditioning (IPo) protects against lung injury induced by intestinal ischemia-reperfusion (IIR) partly through promotion of expression and function of heme oxygenase-1 (HO-1). NF-E2-related factor-2 (Nrf2) is a key transcription factor that interacts with HO-1 and regulates antioxidant defense. However, the role of Nrf2 in IPo protection of IIR-induced pulmonary injury is not completely understood. Here we show that IPo significantly attenuated IIR-induced lung injury and suppressed oxidative stress and systemic inflammatory responses. IPo also increased the expression of both Nrf2 and HO-1. Consistently, the beneficial effects of IPo were abolished by ATRA and Brusatol, potent inhibitors of Nrf2. Moreover, the Nrf2 agonist t-BHQ showed similar activity as IPo. Taken together, our data suggest that Nrf2 activity, along with HO-1, plays an important role in the protective effects of IPo against IIR-induced acute lung injury.

Original languageEnglish
Pages (from-to)1087-1104
Number of pages18
JournalLaboratory Investigation
Volume96
Issue number10
DOIs
StatePublished - Oct 1 2016

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