Obesity disrupts physiological homeostasis and alters both systemic and local microenvironments that impact stem cell plasticity and impair regenerative capacity. We present growing evidence that reveals the bidirectionality of obesity-induced stem cell dysfunction and how the molecular changes in stem cells residing in obese environments may accelerate disease severity.

Original languageEnglish
Pages (from-to)15-18
Number of pages4
JournalCell Stem Cell
Issue number1
StatePublished - Jul 2 2020


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