TY - JOUR
T1 - Is myocardial recovery possible and how do you measure it?
AU - Mann, Douglas L.
AU - Burkhoff, Daniel
N1 - Funding Information:
Acknowledgments This research was supported by research funds from the National Institutes of Health (RO1 HL58081, RO1 HL61543, RO1 HL-42250).
PY - 2012/6
Y1 - 2012/6
N2 - Medical and device therapies that reduce heart failure morbidity and mortality also lead to decreased left ventricular volume and mass, and a more normal elliptical shape of the ventricle. These are due to changes in myocyte size, structure, and organization that have been referred to collectively as "reverse remodeling." Moreover, there are subsets of patients whose hearts have undergone reverse remodeling following mechanical circulatory support with a ventricular assist device (VAD), who are able to be weaned from their VADs, which has been referred to as "myocardial recovery." Although the term myocardial recovery has been used to describe the reversal of various aspects of the heart failure phenotype following medical and device therapy, there is no consensus with regard to what constitutes myocardial recovery; moreover, the methodology for identifying myocardial recovery in patients is unclear. These topics will be discussed in the current review.
AB - Medical and device therapies that reduce heart failure morbidity and mortality also lead to decreased left ventricular volume and mass, and a more normal elliptical shape of the ventricle. These are due to changes in myocyte size, structure, and organization that have been referred to collectively as "reverse remodeling." Moreover, there are subsets of patients whose hearts have undergone reverse remodeling following mechanical circulatory support with a ventricular assist device (VAD), who are able to be weaned from their VADs, which has been referred to as "myocardial recovery." Although the term myocardial recovery has been used to describe the reversal of various aspects of the heart failure phenotype following medical and device therapy, there is no consensus with regard to what constitutes myocardial recovery; moreover, the methodology for identifying myocardial recovery in patients is unclear. These topics will be discussed in the current review.
KW - Cardiac remodeling
KW - Heart failure
KW - Myocardial recovery
KW - Reverse remodeling
UR - http://www.scopus.com/inward/record.url?scp=84861101916&partnerID=8YFLogxK
U2 - 10.1007/s11886-012-0264-z
DO - 10.1007/s11886-012-0264-z
M3 - Review article
C2 - 22437373
AN - SCOPUS:84861101916
SN - 1523-3782
VL - 14
SP - 293
EP - 298
JO - Current Cardiology Reports
JF - Current Cardiology Reports
IS - 3
ER -