TY - JOUR
T1 - Is Mycobacterium tuberculosis stressed out? A critical assessment of the genetic evidence
AU - Stallings, Christina L.
AU - Glickman, Michael S.
N1 - Funding Information:
We apologize to the investigators whose work was not cited because of space constraints. MSG is supported by NIH grant AI80628 and AI53417 . CLS is supported by AI075805 .
PY - 2010/12
Y1 - 2010/12
N2 - Mycobacterium tuberculosis is an obligate human intracellular pathogen which remains a major killer worldwide. A remarkable feature of M. tuberculosis infection is the ability of the pathogen to persist within the host for decades despite an impressive onslaught of stresses. In this review we seek to outline the host-inflicted stresses experienced by M. tuberculosis, the bacterial strategies used to withstand these stresses, and how this information should guide our efforts to combat this global pathogen.
AB - Mycobacterium tuberculosis is an obligate human intracellular pathogen which remains a major killer worldwide. A remarkable feature of M. tuberculosis infection is the ability of the pathogen to persist within the host for decades despite an impressive onslaught of stresses. In this review we seek to outline the host-inflicted stresses experienced by M. tuberculosis, the bacterial strategies used to withstand these stresses, and how this information should guide our efforts to combat this global pathogen.
KW - Mycobacterium tuberculosis
KW - Pathogenesis
KW - Stress responses
UR - http://www.scopus.com/inward/record.url?scp=78649895979&partnerID=8YFLogxK
U2 - 10.1016/j.micinf.2010.07.014
DO - 10.1016/j.micinf.2010.07.014
M3 - Short survey
C2 - 20691805
AN - SCOPUS:78649895979
SN - 1286-4579
VL - 12
SP - 1091
EP - 1101
JO - Microbes and Infection
JF - Microbes and Infection
IS - 14-15
ER -