Mycobacterium tuberculosis is an obligate human intracellular pathogen which remains a major killer worldwide. A remarkable feature of M. tuberculosis infection is the ability of the pathogen to persist within the host for decades despite an impressive onslaught of stresses. In this review we seek to outline the host-inflicted stresses experienced by M. tuberculosis, the bacterial strategies used to withstand these stresses, and how this information should guide our efforts to combat this global pathogen.

Original languageEnglish
Pages (from-to)1091-1101
Number of pages11
JournalMicrobes and Infection
Issue number14-15
StatePublished - Dec 2010


  • Mycobacterium tuberculosis
  • Pathogenesis
  • Stress responses


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