Is lipophosphoglycan a virulence factor? A surprising diversity between Leishmania species

Salvatore J. Turco, Gerald F. Späth, Stephen M. Beverley

Research output: Contribution to journalReview articlepeer-review

136 Scopus citations

Abstract

Lipophosphoglycan is a prominent member of the phosphoglycan-containing surface glycoconjugates of Leishmania. Genetic tests enable confirmation of its role in parasite virulence and permit discrimination between the roles of lipophosphoglycan and related glycoconjugates. When two different lipophosphoglycan biosynthetic genes from Leishmania major were knocked out, there was a clear loss of virulence in several steps of the infectious cycle but, with Leishmania mexicana, no effect on virulence was found. This points to an unexpected diversity in the reliance of Leishmania species on virulence factors, a finding underscored by recent studies showing great diversity in the host response to Leishmania species.

Original languageEnglish
Pages (from-to)223-226
Number of pages4
JournalTrends in Parasitology
Volume17
Issue number5
DOIs
StatePublished - 2001

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