Is enteral administration of fluorine-18-fluorodeoxyglucose (F-18 FDG) a palatable alternative to IV injection? Pre-clinical evaluation in normal rodents

T. Higashi, S. J. Fisher, K. Nakada, D. J. Romain, R. L. Wahl

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

To establish effective methods of enteral 2-[18F]-fluoro-2-deoxy-D-glucose (FDG) administration, the efficiency of FDG absorption in the gastrointestinal tracts following enteral administrations was evaluated using the FDG biodistribution in normal rodents, in combination with various fasting conditions and FDG diluents. The blood FDG curve using hypotonic solution showed a rapid increase, while that in iso- and hypertonic groups showed slow rises. Brain FDG uptake had a close positive correlation with blood AUC (area under curve) and an inverse relationship with the stomach contents.

Original languageEnglish
Pages (from-to)363-373
Number of pages11
JournalNuclear Medicine and Biology
Volume29
Issue number3
DOIs
StatePublished - Jan 1 2002
Externally publishedYes

Keywords

  • 2-[18F]-fluoro-2-deoxy-D-glucose
  • Gastric emptying
  • Gastrointestinal tract
  • Glucose absorption

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