@article{6b79b46ad66649b6b5cd9595e8e78e91,
title = "Is enteral administration of fluorine-18-fluorodeoxyglucose (F-18 FDG) a palatable alternative to IV injection? Pre-clinical evaluation in normal rodents",
abstract = "To establish effective methods of enteral 2-[18F]-fluoro-2-deoxy-D-glucose (FDG) administration, the efficiency of FDG absorption in the gastrointestinal tracts following enteral administrations was evaluated using the FDG biodistribution in normal rodents, in combination with various fasting conditions and FDG diluents. The blood FDG curve using hypotonic solution showed a rapid increase, while that in iso- and hypertonic groups showed slow rises. Brain FDG uptake had a close positive correlation with blood AUC (area under curve) and an inverse relationship with the stomach contents.",
keywords = "2-[18F]-fluoro-2-deoxy-D-glucose, Gastric emptying, Gastrointestinal tract, Glucose absorption",
author = "T. Higashi and Fisher, {S. J.} and K. Nakada and Romain, {D. J.} and Wahl, {R. L.}",
note = "Funding Information: We would like to thank the staff of our laboratory at the University of Michigan Medical Center, Ann Arbor, MI, for support in the preparation of this study; especially Suzanne Carlson, of the University of Michigan Medical Center, Ann Arbor, MI, for valuable advice regarding the manuscript. We are indebted to the staff of the PET center, the University of Michigan Medical Center, Ann Arbor, MI for their assistance in F-18 FDG preparation; especially Mr. Louis JM Tluczek for valuable comments on pharmacochemistry of F-18 FDG. This work was supported by CA52880, awarded by the National Cancer Institute, National Institutes of Health.",
year = "2002",
doi = "10.1016/S0969-8051(01)00312-2",
language = "English",
volume = "29",
pages = "363--373",
journal = "Nuclear Medicine and Biology",
issn = "0969-8051",
number = "3",
}