Is chorionic villus sampling associated with hypertensive disorders of pregnancy?

Anthony O. Odibo, Ashima Singla, Diana L. Gray, Jeffrey M. Dicke, Barbara Oberle, James Crane

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Objective: Our objective is to evaluate for potential associations between chorionic villus sampling (CVS) and hypertensive disorders of pregnancy. Methods: Using our genetic database, we compared the rates of hypertensive disorders between women who underwent CVS at 10-13 and 6/7 weeks with those seen for other indications at similar gestational ages who had no invasive procedure. Only singleton and euploid pregnancies were included. Statistical methods including univariable and multivariable logistic regression, supplemented by stratified analyses were used for comparisons. Results: Among 11 012 pregnant women seen between 1990 and 2006 in our center and meeting the inclusion criteria, information on hypertensive disorders of pregnancy were available in 9386, and 9098 met the inclusion criteria. The overall incidence of hypertensive disorders was 421/9098 (4.6%), with 138/5096 (2.7%) in the CVS group and 283/4002 (7.1%) in the control group [adjusted odds ratio (adjOR) 0.47, 95% confidence interval (CI), 0.38-0.59]. Similar findings were seen on stratified analyses for gestational age of procedure and the type or severity of hypertensive disorder, and other potential confounders. Conclusion: The rate of hypertensive disorders of pregnancy is significantly lower in women having CVS compared with the control group. Placental disruption from CVS is not associated with preeclampsia or gestational hypertension.

Original languageEnglish
Pages (from-to)9-13
Number of pages5
JournalPrenatal Diagnosis
Issue number1
StatePublished - Jan 2010


  • Chorionic villus sampling
  • Fetal and placental pathology
  • Fetal therapy
  • Genetic counseling
  • Hypertensive disorders
  • Preeclampsia


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