Is Axonal Degeneration a Key Early Event in Parkinson's Disease?

Zuzanna Kurowska, Jeffrey H. Kordower, A. Jon Stoessl, Robert E. Burke, Patrik Brundin, Zhenyu Yue, Scott T. Brady, Jeffrey Milbrandt, Bruce D. Trapp, Todd B. Sherer, Satish Medicetty

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21 Scopus citations

Abstract

Recent research suggests that in Parkinson's disease the long, thin and unmyelinated axons of dopaminergic neurons degenerate early in the disease process. We organized a workshop entitled 'Axonal Pathology in Parkinson's disease', on March 23rd, 2016, in Cleveland, Ohio with the goals of summarizing the state-of-the-art and defining key gaps in knowledge. A group of eight research leaders discussed new developments in clinical pathology, functional imaging, animal models, and mechanisms of degeneration including neuroinflammation, autophagy and axonal transport deficits. While the workshop focused on PD, comparisons were made to other neurological conditions where axonal degeneration is well recognized.

Original languageEnglish
Pages (from-to)703-707
Number of pages5
JournalJournal of Parkinson's Disease
Volume6
Issue number4
DOIs
StatePublished - Jan 1 2016

Keywords

  • Parkinson disease
  • animal disease models
  • autophagy
  • axonal transport
  • axons
  • dopaminergic neurons
  • retrograde degeneration
  • review
  • substantia nigra pars compacta
  • synapses

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    Kurowska, Z., Kordower, J. H., Stoessl, A. J., Burke, R. E., Brundin, P., Yue, Z., Brady, S. T., Milbrandt, J., Trapp, B. D., Sherer, T. B., & Medicetty, S. (2016). Is Axonal Degeneration a Key Early Event in Parkinson's Disease? Journal of Parkinson's Disease, 6(4), 703-707. https://doi.org/10.3233/JPD-160881