The goal of this chapter is to provide evidence and justification for the hypothesis that autogenous, posttranscriptional regulation of gene expression is common. Several examples are known, mostly from bacteria, bacteriophage, and yeast species. Each was identified either by accident or by a concerted effort to understand the regulation of specific genes. The paucity of examples from higher eukaryotes may be due to the difficulty of identifying them using common approaches for uncovering regulatory interactions. An alternative approach is proposed that can fill the gap.