Abstract
A practical and highly stereoselective iron-catalyzed cross-coupling reaction of stereodefined enol carbamates and Grignard reagents to yield tri- and tetrasubstituted acrylates is reported. A facile method for the stereoselective generation of these enol carbamates has also been developed. Ironing out olefin synthesis: A practical and highly stereoselective iron-catalyzed cross-coupling reaction between stereodefined enol carbamates and alkyl Grignard reagents yields tri- and tetrasubstituted acrylates. A facile method for the stereoselective generation of these enol carbamates is also reported.
| Original language | English |
|---|---|
| Pages (from-to) | 6689-6693 |
| Number of pages | 5 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 55 |
| Issue number | 23 |
| DOIs | |
| State | Published - Jun 1 2016 |
Keywords
- acrylates
- cross-coupling
- enol carbamates
- iron catalysis
- stereoselective synthesis