IRhoms: ERADicating the Messenger in Growth Control Signaling

Stewart Siyan Cao; Randal J. Kaufman

doi:10.1016/j.devcel.2011.04.003

IRhoms: ERADicating the Messenger in Growth Control Signaling

Stewart Siyan Cao, Randal J. Kaufman

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

iRhoms are inactive rhomboid-like pseudoproteases that lack essential catalytic residues. Although iRhoms are highly conserved in metazoan species, little is known about their function. In a recent issue of Cell, Zettl et al. (2011) show that iRhoms regulate growth factor signaling through endoplasmic reticulum-associated protein degradation (ERAD).

Original language	English
Pages (from-to)	414-416
Number of pages	3
Journal	Developmental cell
Volume	20
Issue number	4
DOIs	https://doi.org/10.1016/j.devcel.2011.04.003
State	Published - Apr 19 2011

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@article{d52da53d294b4b2fae9460f1078288c4,

title = "IRhoms: ERADicating the Messenger in Growth Control Signaling",

abstract = "iRhoms are inactive rhomboid-like pseudoproteases that lack essential catalytic residues. Although iRhoms are highly conserved in metazoan species, little is known about their function. In a recent issue of Cell, Zettl et al. (2011) show that iRhoms regulate growth factor signaling through endoplasmic reticulum-associated protein degradation (ERAD).",

author = "Cao, {Stewart Siyan} and Kaufman, {Randal J.}",

year = "2011",

month = apr,

day = "19",

doi = "10.1016/j.devcel.2011.04.003",

language = "English",

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pages = "414--416",

journal = "Developmental Cell",

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TY - JOUR

T1 - IRhoms

T2 - ERADicating the Messenger in Growth Control Signaling

AU - Cao, Stewart Siyan

AU - Kaufman, Randal J.

PY - 2011/4/19

Y1 - 2011/4/19

N2 - iRhoms are inactive rhomboid-like pseudoproteases that lack essential catalytic residues. Although iRhoms are highly conserved in metazoan species, little is known about their function. In a recent issue of Cell, Zettl et al. (2011) show that iRhoms regulate growth factor signaling through endoplasmic reticulum-associated protein degradation (ERAD).

AB - iRhoms are inactive rhomboid-like pseudoproteases that lack essential catalytic residues. Although iRhoms are highly conserved in metazoan species, little is known about their function. In a recent issue of Cell, Zettl et al. (2011) show that iRhoms regulate growth factor signaling through endoplasmic reticulum-associated protein degradation (ERAD).

UR - http://www.scopus.com/inward/record.url?scp=79954462193&partnerID=8YFLogxK

U2 - 10.1016/j.devcel.2011.04.003

DO - 10.1016/j.devcel.2011.04.003

M3 - Short survey

AN - SCOPUS:79954462193

SN - 1534-5807

VL - 20

SP - 414

EP - 416

JO - Developmental Cell

JF - Developmental Cell

IS - 4

ER -

IRhoms: ERADicating the Messenger in Growth Control Signaling

Abstract

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