IRhoms: ERADicating the Messenger in Growth Control Signaling

Stewart Siyan Cao, Randal J. Kaufman

Research output: Contribution to journalShort surveypeer-review

1 Scopus citations


iRhoms are inactive rhomboid-like pseudoproteases that lack essential catalytic residues. Although iRhoms are highly conserved in metazoan species, little is known about their function. In a recent issue of Cell, Zettl et al. (2011) show that iRhoms regulate growth factor signaling through endoplasmic reticulum-associated protein degradation (ERAD).

Original languageEnglish
Pages (from-to)414-416
Number of pages3
JournalDevelopmental cell
Issue number4
StatePublished - Apr 19 2011


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