IRE1, a Double-Edged Sword in Pre-miRNA Slicing and Cell Death

Justin Hassler; Stewart S. Cao; Randal J. Kaufman

doi:10.1016/j.devcel.2012.10.025

IRE1, a Double-Edged Sword in Pre-miRNA Slicing and Cell Death

Justin Hassler, Stewart S. Cao, Randal J. Kaufman

Research output: Contribution to journal › Short survey › peer-review

64 Scopus citations

Abstract

IRE1α, the most conserved transducer of the unfolded protein response, plays critical roles in many biological processes and cell fate decisions. Reporting in Science, Upton et al. (2012) broadened our understanding of IRE1α as a cell-death executioner, showing that upon ER stress, IRE1α degrades microRNAs to promote translation of caspase-2.

Original language	English
Pages (from-to)	921-923
Number of pages	3
Journal	Developmental cell
Volume	23
Issue number	5
DOIs	https://doi.org/10.1016/j.devcel.2012.10.025
State	Published - Nov 13 2012

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10.1016/j.devcel.2012.10.025

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title = "IRE1, a Double-Edged Sword in Pre-miRNA Slicing and Cell Death",

abstract = "IRE1α, the most conserved transducer of the unfolded protein response, plays critical roles in many biological processes and cell fate decisions. Reporting in Science, Upton et al. (2012) broadened our understanding of IRE1α as a cell-death executioner, showing that upon ER stress, IRE1α degrades microRNAs to promote translation of caspase-2.",

author = "Justin Hassler and Cao, {Stewart S.} and Kaufman, {Randal J.}",

year = "2012",

month = nov,

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AU - Hassler, Justin

AU - Cao, Stewart S.

AU - Kaufman, Randal J.

PY - 2012/11/13

Y1 - 2012/11/13

N2 - IRE1α, the most conserved transducer of the unfolded protein response, plays critical roles in many biological processes and cell fate decisions. Reporting in Science, Upton et al. (2012) broadened our understanding of IRE1α as a cell-death executioner, showing that upon ER stress, IRE1α degrades microRNAs to promote translation of caspase-2.

AB - IRE1α, the most conserved transducer of the unfolded protein response, plays critical roles in many biological processes and cell fate decisions. Reporting in Science, Upton et al. (2012) broadened our understanding of IRE1α as a cell-death executioner, showing that upon ER stress, IRE1α degrades microRNAs to promote translation of caspase-2.

UR - http://www.scopus.com/inward/record.url?scp=84869049922&partnerID=8YFLogxK

U2 - 10.1016/j.devcel.2012.10.025

DO - 10.1016/j.devcel.2012.10.025

M3 - Short survey

AN - SCOPUS:84869049922

SN - 1534-5807

VL - 23

SP - 921

EP - 923

JO - Developmental cell

JF - Developmental cell

IS - 5

ER -

IRE1, a Double-Edged Sword in Pre-miRNA Slicing and Cell Death

Abstract

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