Ipsi- and contralateral motor response using ultrasound-induced neurostimulation in deeply anesthetized mice

Hermes Kamimura; Shutao Wang; Hong Chen; Qi Wang; Christian Aurup; Kathtleen Fan; Antonio Carneiro; Elisa Konofagou

doi:10.1016/j.phpro.2015.08.261

Ipsi- and contralateral motor response using ultrasound-induced neurostimulation in deeply anesthetized mice

Hermes Kamimura, Shutao Wang, Hong Chen, Qi Wang, Christian Aurup, Kathtleen Fan, Antonio Carneiro, Elisa Konofagou

Research output: Contribution to journal › Conference article › peer-review

3 Scopus citations

Abstract

Ultrasound neurostimulation has been proven capable of eliciting motor responses. However, the studies in sedated rodents presented problems with target specificity due to the use of low ultrasound frequencies (<700 kHz). Here, we show that focused ultrasound (FUS) in mega-Hz range was able to evoke motor responses in mice under deep anesthesia. Contralateral movements of the hind limbs were observed when sonications were carried out at +2 mm of Lambda and ±2 mm lateral of midline in three mice. Moreover, stimulating other regions of the somatosensory and cerebellum induced trunk and ipsilateral limb movements in all six mice.

Original language	English
Pages (from-to)	1212-1215
Number of pages	4
Journal	Physics Procedia
Volume	70
DOIs	https://doi.org/10.1016/j.phpro.2015.08.261
State	Published - 2015
Event	ICU International Congress on Ultrasonics, ICU 2015 - Metz, France Duration: May 11 2015 → May 14 2015

Keywords

Evoked motor response
neurostimulation
ultrasound

Access to Document

10.1016/j.phpro.2015.08.261

Cite this

@article{3043edc46aae46b1a706fd92b45811b4,

title = "Ipsi- and contralateral motor response using ultrasound-induced neurostimulation in deeply anesthetized mice",

abstract = "Ultrasound neurostimulation has been proven capable of eliciting motor responses. However, the studies in sedated rodents presented problems with target specificity due to the use of low ultrasound frequencies (<700 kHz). Here, we show that focused ultrasound (FUS) in mega-Hz range was able to evoke motor responses in mice under deep anesthesia. Contralateral movements of the hind limbs were observed when sonications were carried out at +2 mm of Lambda and ±2 mm lateral of midline in three mice. Moreover, stimulating other regions of the somatosensory and cerebellum induced trunk and ipsilateral limb movements in all six mice.",

keywords = "Evoked motor response, neurostimulation, ultrasound",

author = "Hermes Kamimura and Shutao Wang and Hong Chen and Qi Wang and Christian Aurup and Kathtleen Fan and Antonio Carneiro and Elisa Konofagou",

note = "Publisher Copyright: {\textcopyright} 2015 The Authors.; ICU International Congress on Ultrasonics, ICU 2015 ; Conference date: 11-05-2015 Through 14-05-2015",

year = "2015",

doi = "10.1016/j.phpro.2015.08.261",

language = "English",

volume = "70",

pages = "1212--1215",

journal = "Physics Procedia",

issn = "1875-3884",

}

TY - JOUR

T1 - Ipsi- and contralateral motor response using ultrasound-induced neurostimulation in deeply anesthetized mice

AU - Kamimura, Hermes

AU - Wang, Shutao

AU - Chen, Hong

AU - Wang, Qi

AU - Aurup, Christian

AU - Fan, Kathtleen

AU - Carneiro, Antonio

AU - Konofagou, Elisa

PY - 2015

Y1 - 2015

N2 - Ultrasound neurostimulation has been proven capable of eliciting motor responses. However, the studies in sedated rodents presented problems with target specificity due to the use of low ultrasound frequencies (<700 kHz). Here, we show that focused ultrasound (FUS) in mega-Hz range was able to evoke motor responses in mice under deep anesthesia. Contralateral movements of the hind limbs were observed when sonications were carried out at +2 mm of Lambda and ±2 mm lateral of midline in three mice. Moreover, stimulating other regions of the somatosensory and cerebellum induced trunk and ipsilateral limb movements in all six mice.

AB - Ultrasound neurostimulation has been proven capable of eliciting motor responses. However, the studies in sedated rodents presented problems with target specificity due to the use of low ultrasound frequencies (<700 kHz). Here, we show that focused ultrasound (FUS) in mega-Hz range was able to evoke motor responses in mice under deep anesthesia. Contralateral movements of the hind limbs were observed when sonications were carried out at +2 mm of Lambda and ±2 mm lateral of midline in three mice. Moreover, stimulating other regions of the somatosensory and cerebellum induced trunk and ipsilateral limb movements in all six mice.

KW - Evoked motor response

KW - neurostimulation

KW - ultrasound

UR - http://www.scopus.com/inward/record.url?scp=84948672903&partnerID=8YFLogxK

U2 - 10.1016/j.phpro.2015.08.261

DO - 10.1016/j.phpro.2015.08.261

M3 - Conference article

AN - SCOPUS:84948672903

SN - 1875-3884

VL - 70

SP - 1212

EP - 1215

JO - Physics Procedia

JF - Physics Procedia

T2 - ICU International Congress on Ultrasonics, ICU 2015

Y2 - 11 May 2015 through 14 May 2015

ER -

Ipsi- and contralateral motor response using ultrasound-induced neurostimulation in deeply anesthetized mice

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this