TY - JOUR
T1 - iPLA 2 β and its role in male fertility, neurological disorders, metabolic disorders, and inflammation
AU - Turk, John
AU - White, Tayleur D.
AU - Nelson, Alexander J.
AU - Lei, Xiaoyong
AU - Ramanadham, Sasanka
N1 - Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2019/6
Y1 - 2019/6
N2 - The Ca 2+ -independent phospholipases, designated as group VI iPLA 2 s, also referred to as PNPLAs due to their shared homology with patatin, include the β, γ, δ, ε, ζ, and η forms of the enzyme. The iPLA 2 s are ubiquitously expressed, share a consensus GXSXG catalytic motif, and exhibit organelle/cell-specific localization. Among the iPLA 2 s, iPLA 2 β has received wide attention as it is recognized to be involved in membrane remodeling, cell proliferation, cell death, and signal transduction. Ongoing studies implicate participation of iPLA 2 β in a variety of disease processes including cancer, cardiovascular abnormalities, glaucoma, and peridonditis. This review will focus on iPLA 2 β and its links to male fertility, neurological disorders, metabolic disorders, and inflammation.
AB - The Ca 2+ -independent phospholipases, designated as group VI iPLA 2 s, also referred to as PNPLAs due to their shared homology with patatin, include the β, γ, δ, ε, ζ, and η forms of the enzyme. The iPLA 2 s are ubiquitously expressed, share a consensus GXSXG catalytic motif, and exhibit organelle/cell-specific localization. Among the iPLA 2 s, iPLA 2 β has received wide attention as it is recognized to be involved in membrane remodeling, cell proliferation, cell death, and signal transduction. Ongoing studies implicate participation of iPLA 2 β in a variety of disease processes including cancer, cardiovascular abnormalities, glaucoma, and peridonditis. This review will focus on iPLA 2 β and its links to male fertility, neurological disorders, metabolic disorders, and inflammation.
KW - Diabetes
KW - Immune responses
KW - Membrane remodeling
KW - Signaling
KW - iPLA β-derived lipids
UR - https://www.scopus.com/pages/publications/85056480447
U2 - 10.1016/j.bbalip.2018.10.010
DO - 10.1016/j.bbalip.2018.10.010
M3 - Review article
C2 - 30408523
AN - SCOPUS:85056480447
SN - 1388-1981
VL - 1864
SP - 846
EP - 860
JO - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
JF - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
IS - 6
ER -