TY - JOUR
T1 - Ionizing radiation improves survival in mice bearing intracranial high- grade gliomas injected with genetically modified herpes simplex virus
AU - Bradley, Jeffrey D.
AU - Kataoka, Yasushi
AU - Advani, Sunil
AU - Chung, Su Mi
AU - Arani, Ramin B.
AU - Gillespie, G. Yancey
AU - Whitley, Richard J.
AU - Markert, James M.
AU - Roizman, Bernard
AU - Weichselbaum, Ralph R.
PY - 1999/6
Y1 - 1999/6
N2 - Malignant gliomas remain incurable with current interventions. Encouraging investigational approaches include the use of genetically modified herpes simplex-1 (HSV-1) viruses as direct cytotoxic agents. Combining attenuated HSV-1 with standard therapy, human U-87 malignant glioma xenografts grown in the hind limb or intracranially in athymic nude mice were exposed to ionizing radiation, in, oculated with genetically modified HSV R3616, or received both virus and radiation. The combination of virus with fractionated ionizing radiation suggests a synergistic action and results in reduced tumor volumes and longer survivals when compared with treatment with either modality alone.
AB - Malignant gliomas remain incurable with current interventions. Encouraging investigational approaches include the use of genetically modified herpes simplex-1 (HSV-1) viruses as direct cytotoxic agents. Combining attenuated HSV-1 with standard therapy, human U-87 malignant glioma xenografts grown in the hind limb or intracranially in athymic nude mice were exposed to ionizing radiation, in, oculated with genetically modified HSV R3616, or received both virus and radiation. The combination of virus with fractionated ionizing radiation suggests a synergistic action and results in reduced tumor volumes and longer survivals when compared with treatment with either modality alone.
UR - http://www.scopus.com/inward/record.url?scp=0033018852&partnerID=8YFLogxK
M3 - Article
C2 - 10389941
AN - SCOPUS:0033018852
SN - 1078-0432
VL - 5
SP - 1517
EP - 1522
JO - Clinical Cancer Research
JF - Clinical Cancer Research
IS - 6
ER -