Ionic-liquid matrices for improved analysis of phospholipids by MALDI-TOF mass spectrometry

Ying L. Li; Michael L. Gross; Fong Fu Hsu

doi:10.1016/j.jasms.2005.01.017

Ionic-liquid matrices for improved analysis of phospholipids by MALDI-TOF mass spectrometry

Research output: Contribution to journal › Article › peer-review

Abstract

The use of ionic liquid matrices (ILMs) for phospholipids (PLs) affords higher signal intensity, smaller spot size, improved spot homogeneity, better signal reproducibility, and comparable or better detection limits compared to that of the crystalline matrix 2,5-dihydroxybenzoic acid (2,5-DHB). The ionization products are comparable to those with 2,5-DHB although the use of ILMs gives a stronger tendency to produce alkali-metal-ion adducts and a lower extent of prompt fragmentation.

Original language	English
Pages (from-to)	679-682
Number of pages	4
Journal	Journal of the American Society for Mass Spectrometry
Volume	16
Issue number	5
DOIs	https://doi.org/10.1016/j.jasms.2005.01.017
State	Published - May 2005

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10.1016/j.jasms.2005.01.017

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title = "Ionic-liquid matrices for improved analysis of phospholipids by MALDI-TOF mass spectrometry",

abstract = "The use of ionic liquid matrices (ILMs) for phospholipids (PLs) affords higher signal intensity, smaller spot size, improved spot homogeneity, better signal reproducibility, and comparable or better detection limits compared to that of the crystalline matrix 2,5-dihydroxybenzoic acid (2,5-DHB). The ionization products are comparable to those with 2,5-DHB although the use of ILMs gives a stronger tendency to produce alkali-metal-ion adducts and a lower extent of prompt fragmentation.",

author = "Li, \{Ying L.\} and Gross, \{Michael L.\} and Hsu, \{Fong Fu\}",

note = "Funding Information: This research was supported by the National Centers of Research Resources of the National Institutes of Health of the U.S. (grant P41RR00954).",

year = "2005",

month = may,

doi = "10.1016/j.jasms.2005.01.017",

language = "English",

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pages = "679--682",

journal = "Journal of the American Society for Mass Spectrometry",

issn = "1044-0305",

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T1 - Ionic-liquid matrices for improved analysis of phospholipids by MALDI-TOF mass spectrometry

AU - Li, Ying L.

AU - Gross, Michael L.

AU - Hsu, Fong Fu

N1 - Funding Information: This research was supported by the National Centers of Research Resources of the National Institutes of Health of the U.S. (grant P41RR00954).

PY - 2005/5

Y1 - 2005/5

N2 - The use of ionic liquid matrices (ILMs) for phospholipids (PLs) affords higher signal intensity, smaller spot size, improved spot homogeneity, better signal reproducibility, and comparable or better detection limits compared to that of the crystalline matrix 2,5-dihydroxybenzoic acid (2,5-DHB). The ionization products are comparable to those with 2,5-DHB although the use of ILMs gives a stronger tendency to produce alkali-metal-ion adducts and a lower extent of prompt fragmentation.

AB - The use of ionic liquid matrices (ILMs) for phospholipids (PLs) affords higher signal intensity, smaller spot size, improved spot homogeneity, better signal reproducibility, and comparable or better detection limits compared to that of the crystalline matrix 2,5-dihydroxybenzoic acid (2,5-DHB). The ionization products are comparable to those with 2,5-DHB although the use of ILMs gives a stronger tendency to produce alkali-metal-ion adducts and a lower extent of prompt fragmentation.

UR - https://www.scopus.com/pages/publications/18044366370

U2 - 10.1016/j.jasms.2005.01.017

DO - 10.1016/j.jasms.2005.01.017

M3 - Article

C2 - 15862769

AN - SCOPUS:18044366370

SN - 1044-0305

VL - 16

SP - 679

EP - 682

JO - Journal of the American Society for Mass Spectrometry

JF - Journal of the American Society for Mass Spectrometry

IS - 5

ER -

Ionic-liquid matrices for improved analysis of phospholipids by MALDI-TOF mass spectrometry

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