Ionic-liquid matrices for improved analysis of phospholipids by MALDI-TOF mass spectrometry

Ying L. Li, Michael L. Gross, Fong Fu Hsu

Research output: Contribution to journalArticlepeer-review

110 Scopus citations

Abstract

The use of ionic liquid matrices (ILMs) for phospholipids (PLs) affords higher signal intensity, smaller spot size, improved spot homogeneity, better signal reproducibility, and comparable or better detection limits compared to that of the crystalline matrix 2,5-dihydroxybenzoic acid (2,5-DHB). The ionization products are comparable to those with 2,5-DHB although the use of ILMs gives a stronger tendency to produce alkali-metal-ion adducts and a lower extent of prompt fragmentation.

Original languageEnglish
Pages (from-to)679-682
Number of pages4
JournalJournal of the American Society for Mass Spectrometry
Volume16
Issue number5
DOIs
StatePublished - May 2005

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