TY - JOUR
T1 - Ionic-liquid matrices for improved analysis of phospholipids by MALDI-TOF mass spectrometry
AU - Li, Ying L.
AU - Gross, Michael L.
AU - Hsu, Fong Fu
N1 - Funding Information:
This research was supported by the National Centers of Research Resources of the National Institutes of Health of the U.S. (grant P41RR00954).
PY - 2005/5
Y1 - 2005/5
N2 - The use of ionic liquid matrices (ILMs) for phospholipids (PLs) affords higher signal intensity, smaller spot size, improved spot homogeneity, better signal reproducibility, and comparable or better detection limits compared to that of the crystalline matrix 2,5-dihydroxybenzoic acid (2,5-DHB). The ionization products are comparable to those with 2,5-DHB although the use of ILMs gives a stronger tendency to produce alkali-metal-ion adducts and a lower extent of prompt fragmentation.
AB - The use of ionic liquid matrices (ILMs) for phospholipids (PLs) affords higher signal intensity, smaller spot size, improved spot homogeneity, better signal reproducibility, and comparable or better detection limits compared to that of the crystalline matrix 2,5-dihydroxybenzoic acid (2,5-DHB). The ionization products are comparable to those with 2,5-DHB although the use of ILMs gives a stronger tendency to produce alkali-metal-ion adducts and a lower extent of prompt fragmentation.
UR - http://www.scopus.com/inward/record.url?scp=18044366370&partnerID=8YFLogxK
U2 - 10.1016/j.jasms.2005.01.017
DO - 10.1016/j.jasms.2005.01.017
M3 - Article
C2 - 15862769
AN - SCOPUS:18044366370
SN - 1044-0305
VL - 16
SP - 679
EP - 682
JO - Journal of the American Society for Mass Spectrometry
JF - Journal of the American Society for Mass Spectrometry
IS - 5
ER -