TY - CHAP
T1 - Ion Channels in the Cell Membrane
T2 - Structure, Function, and Modeling
AU - Wu, D.
AU - Cui, J.
N1 - Funding Information:
Dick Wu is a post-doctoral scholar at Stanford University with Drs. Thomas Südhof and Robert Malenka. He is currently studying proteins involved in exocytosis and synaptic transmission. He received his B.S. in Biomedical Engineering from Northwestern University and Ph.D. in Biomedical Engineering from Washington University in St. Louis with Dr. Jianmin Cui. During his Ph.D. training, he was awarded a predoctoral fellowship from the American Heart Association.
Publisher Copyright:
© 2014 Elsevier B.V. All rights reserved.
PY - 2014/7/25
Y1 - 2014/7/25
N2 - Ion channels are integral membrane proteins found on the membrane of all cells and play important roles in cell signaling. These ubiquitous proteins are evolutionarily conserved in elementary form and function across organisms as diverse as bacteria, flies, and humans - a testament to the fundamental necessity of ion channels for an organism's survival. Diseases linked to ion channel dysfunction, such as epilepsy, cardiac arrhythmias, cystic fibrosis, and diabetes, illustrate the importance of ion channels in physiology. This chapter will examine the structure, function, and physiological roles of ion channels with special emphasis on voltage-gated channels.
AB - Ion channels are integral membrane proteins found on the membrane of all cells and play important roles in cell signaling. These ubiquitous proteins are evolutionarily conserved in elementary form and function across organisms as diverse as bacteria, flies, and humans - a testament to the fundamental necessity of ion channels for an organism's survival. Diseases linked to ion channel dysfunction, such as epilepsy, cardiac arrhythmias, cystic fibrosis, and diabetes, illustrate the importance of ion channels in physiology. This chapter will examine the structure, function, and physiological roles of ion channels with special emphasis on voltage-gated channels.
KW - Action potential
KW - Cardiac myocyte
KW - Ion channel
KW - Neuron
UR - http://www.scopus.com/inward/record.url?scp=84943428867&partnerID=8YFLogxK
U2 - 10.1016/B978-0-444-53632-7.01005-4
DO - 10.1016/B978-0-444-53632-7.01005-4
M3 - Chapter
AN - SCOPUS:84943428867
SN - 9780444536334
VL - 10
SP - 71
EP - 81
BT - Physical Medicine and Rehabilitation
PB - Elsevier
ER -