Inwardly Rectifying Potassium Channels

H. T. Kurata, C. G. Nichols

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Inwardly rectifying potassium (Kir) channels exhibit little or no intrinsic voltage dependence, but their activity can be dramatically influenced by a number of ligands and naturally occurring channel blockers. Kir channels play a critical role in a number of physiological processes and genetic diseases, and recent structural descriptions of a bacterial Kir homolog and isolated domains of eukaryotic Kirs have contributed to our detailed understanding of the function and regulation of these channels. This article describes the critical structural features of Kir channels and the mechanisms underlying channel regulation by polyamine blockers and various ligands, including nucleotides, G βγ subunits, and phospholipids.

Original languageEnglish
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Pages213-219
Number of pages7
ISBN (Print)9780080450469
DOIs
StatePublished - Jan 1 2009

Keywords

  • GIRK
  • Inward rectifier
  • KATP
  • PIP2
  • Polyamine
  • Potassium channel
  • Spermidine
  • Spermine

Fingerprint Dive into the research topics of 'Inwardly Rectifying Potassium Channels'. Together they form a unique fingerprint.

  • Cite this

    Kurata, H. T., & Nichols, C. G. (2009). Inwardly Rectifying Potassium Channels. In Encyclopedia of Neuroscience (pp. 213-219). Elsevier Ltd. https://doi.org/10.1016/B978-008045046-9.01635-1