Functional Kir channels are formed by the homomeric or heteromeric assembly of four subunits, each Kir subunit containing two membrane-spanning domains (TM1 and TM2), an extracellular pore-forming region (H5) that includes the selectivity lter, and cytosolic NH2-and COOH-termini that associate with each other to form a cytoplasmic domain that controls gating (Figure 18.2) (Nishida et al. 2007, Whorton and MacKinnon 2011).

Original languageEnglish
Title of host publicationHandbook of Ion Channels
PublisherCRC Press
Number of pages20
ISBN (Electronic)9781466551428
StatePublished - Jan 1 2015


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