TY - JOUR
T1 - Involvement of the AATn polymorphism of the CNR1 gene in the efficiency of procedural learning in humans
AU - Ruiz-Contreras, Alejandra E.
AU - Delgado-Herrera, Maribel
AU - García-Vaca, Paola A.
AU - Almeida-Rosas, Georgina A.
AU - Soria-Rodríguez, Gerardo
AU - Soriano-Bautista, Alejandro
AU - Cadena-Valencia, Jaime
AU - Bazán-Frías, Jorge R.
AU - Gómez-López, Nardhy
AU - Espejel-Núñez, Aurora
AU - Vadillo-Ortega, Felipe
AU - Carrillo-Sánchez, Karol
AU - Verdín-Reyes, Juan C.
AU - March-Mifsut, Santiago
AU - Méndez-Díaz, Mónica
AU - Prospéro-García, Oscar
PY - 2011/5/2
Y1 - 2011/5/2
N2 - Procedural learning refers to the acquisition of motor skills and the practice that refines their performance. The striatum participates in this learning through a function regulated by endocannabinoid signaling and other systems. This study relates the efficiency in learning a procedural task with the AATn polymorphism of the CNR1 gene, which encodes for the CB1 receptor. The mirror-drawing star task was solved by 99 healthy young subjects in three trials. The sample was divided into high- and low-performance groups based on performance efficiency. AAT12/14 carriers were more frequent in the former group, while there were more AAT12/13 carriers in the latter, which also made more errors/min. Therefore, we characterized two efficiency phenotypes: high- vs. low-performers associated with the two AATn genotypes, AAT12/14 vs. AAT12/13. The findings suggest that AATn polymorphism modifies CNR1 translation, indicating a different modulation of CB1.
AB - Procedural learning refers to the acquisition of motor skills and the practice that refines their performance. The striatum participates in this learning through a function regulated by endocannabinoid signaling and other systems. This study relates the efficiency in learning a procedural task with the AATn polymorphism of the CNR1 gene, which encodes for the CB1 receptor. The mirror-drawing star task was solved by 99 healthy young subjects in three trials. The sample was divided into high- and low-performance groups based on performance efficiency. AAT12/14 carriers were more frequent in the former group, while there were more AAT12/13 carriers in the latter, which also made more errors/min. Therefore, we characterized two efficiency phenotypes: high- vs. low-performers associated with the two AATn genotypes, AAT12/14 vs. AAT12/13. The findings suggest that AATn polymorphism modifies CNR1 translation, indicating a different modulation of CB1.
KW - AATn
KW - CB1
KW - CNR1
KW - Memory
KW - Procedural learning
KW - Striatum
UR - http://www.scopus.com/inward/record.url?scp=79954415542&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2011.03.013
DO - 10.1016/j.neulet.2011.03.013
M3 - Article
C2 - 21396980
AN - SCOPUS:79954415542
SN - 0304-3940
VL - 494
SP - 202
EP - 206
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 3
ER -