Involvement of surfactant protein D in ebola virus infection enhancement via glycoprotein interaction

Anne Laure Favier, Olivier Reynard, Evelyne Gout, Martin van Eijk, Henk P. Haagsman, Erika Crouch, Viktor Volchkov, Christophe Peyrefitte, Nicole M. Thielens

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Since the largest 2014–2016 Ebola virus disease outbreak in West Africa, understanding of Ebola virus infection has improved, notably the involvement of innate immune mediators. Amongst them, collectins are important players in the antiviral innate immune defense. A screening of Ebola glycoprotein (GP)-collectins interactions revealed the specific interaction of human surfactant protein D (hSP-D), a lectin expressed in lung and liver, two compartments where Ebola was found in vivo. Further analyses have demonstrated an involvement of hSP-D in the enhancement of virus infection in several in vitro models. Similar effects were observed for porcine SP-D (pSP-D). In addition, both hSP-D and pSP-D interacted with Reston virus (RESTV) GP and enhanced pseudoviral infection in pulmonary cells. Thus, our study reveals a novel partner of Ebola GP that may participate to enhance viral spread.

Original languageEnglish
Article number15
Issue number1
StatePublished - Jan 2019


  • Collectin
  • Ebola virus
  • Glycoprotein
  • Innate immunity
  • Interaction
  • Pig
  • Reston virus
  • SP-D
  • Surfactant protein


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