Involvement of surfactant protein D in ebola virus infection enhancement via glycoprotein interaction

Anne Laure Favier; Olivier Reynard; Evelyne Gout; Martin van Eijk; Henk P. Haagsman; Erika Crouch; Viktor Volchkov; Christophe Peyrefitte; Nicole M. Thielens

doi:10.3390/v11010015

Involvement of surfactant protein D in ebola virus infection enhancement via glycoprotein interaction

Anne Laure Favier, Olivier Reynard, Evelyne Gout, Martin van Eijk, Henk P. Haagsman, Erika Crouch, Viktor Volchkov, Christophe Peyrefitte, Nicole M. Thielens

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Since the largest 2014–2016 Ebola virus disease outbreak in West Africa, understanding of Ebola virus infection has improved, notably the involvement of innate immune mediators. Amongst them, collectins are important players in the antiviral innate immune defense. A screening of Ebola glycoprotein (GP)-collectins interactions revealed the specific interaction of human surfactant protein D (hSP-D), a lectin expressed in lung and liver, two compartments where Ebola was found in vivo. Further analyses have demonstrated an involvement of hSP-D in the enhancement of virus infection in several in vitro models. Similar effects were observed for porcine SP-D (pSP-D). In addition, both hSP-D and pSP-D interacted with Reston virus (RESTV) GP and enhanced pseudoviral infection in pulmonary cells. Thus, our study reveals a novel partner of Ebola GP that may participate to enhance viral spread.

Original language	English
Article number	15
Journal	Viruses
Volume	11
Issue number	1
DOIs	https://doi.org/10.3390/v11010015
State	Published - Jan 2019

Keywords

Collectin
Ebola virus
Glycoprotein
Innate immunity
Interaction
Pig
Reston virus
SP-D
Surfactant protein

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10.3390/v11010015

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title = "Involvement of surfactant protein D in ebola virus infection enhancement via glycoprotein interaction",

abstract = "Since the largest 2014–2016 Ebola virus disease outbreak in West Africa, understanding of Ebola virus infection has improved, notably the involvement of innate immune mediators. Amongst them, collectins are important players in the antiviral innate immune defense. A screening of Ebola glycoprotein (GP)-collectins interactions revealed the specific interaction of human surfactant protein D (hSP-D), a lectin expressed in lung and liver, two compartments where Ebola was found in vivo. Further analyses have demonstrated an involvement of hSP-D in the enhancement of virus infection in several in vitro models. Similar effects were observed for porcine SP-D (pSP-D). In addition, both hSP-D and pSP-D interacted with Reston virus (RESTV) GP and enhanced pseudoviral infection in pulmonary cells. Thus, our study reveals a novel partner of Ebola GP that may participate to enhance viral spread.",

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AU - Favier, Anne Laure

AU - Reynard, Olivier

AU - Gout, Evelyne

AU - van Eijk, Martin

AU - Haagsman, Henk P.

AU - Crouch, Erika

AU - Volchkov, Viktor

AU - Peyrefitte, Christophe

AU - Thielens, Nicole M.

PY - 2019/1

Y1 - 2019/1

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AB - Since the largest 2014–2016 Ebola virus disease outbreak in West Africa, understanding of Ebola virus infection has improved, notably the involvement of innate immune mediators. Amongst them, collectins are important players in the antiviral innate immune defense. A screening of Ebola glycoprotein (GP)-collectins interactions revealed the specific interaction of human surfactant protein D (hSP-D), a lectin expressed in lung and liver, two compartments where Ebola was found in vivo. Further analyses have demonstrated an involvement of hSP-D in the enhancement of virus infection in several in vitro models. Similar effects were observed for porcine SP-D (pSP-D). In addition, both hSP-D and pSP-D interacted with Reston virus (RESTV) GP and enhanced pseudoviral infection in pulmonary cells. Thus, our study reveals a novel partner of Ebola GP that may participate to enhance viral spread.

KW - Collectin

KW - Ebola virus

KW - Glycoprotein

KW - Innate immunity

KW - Interaction

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KW - Reston virus

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Involvement of surfactant protein D in ebola virus infection enhancement via glycoprotein interaction

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Keywords

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