@article{3fdea849ceea4b69be0002c304836d12,
title = "Involvement of surfactant protein D in ebola virus infection enhancement via glycoprotein interaction",
abstract = "Since the largest 2014–2016 Ebola virus disease outbreak in West Africa, understanding of Ebola virus infection has improved, notably the involvement of innate immune mediators. Amongst them, collectins are important players in the antiviral innate immune defense. A screening of Ebola glycoprotein (GP)-collectins interactions revealed the specific interaction of human surfactant protein D (hSP-D), a lectin expressed in lung and liver, two compartments where Ebola was found in vivo. Further analyses have demonstrated an involvement of hSP-D in the enhancement of virus infection in several in vitro models. Similar effects were observed for porcine SP-D (pSP-D). In addition, both hSP-D and pSP-D interacted with Reston virus (RESTV) GP and enhanced pseudoviral infection in pulmonary cells. Thus, our study reveals a novel partner of Ebola GP that may participate to enhance viral spread.",
keywords = "Collectin, Ebola virus, Glycoprotein, Innate immunity, Interaction, Pig, Reston virus, SP-D, Surfactant protein",
author = "Favier, {Anne Laure} and Olivier Reynard and Evelyne Gout and {van Eijk}, Martin and Haagsman, {Henk P.} and Erika Crouch and Viktor Volchkov and Christophe Peyrefitte and Thielens, {Nicole M.}",
note = "Funding Information: We acknowledge the support of the Direction G{\'e}n{\'e}rale pour l{\textquoteright}Armement (DGA), the Service de Sant{\'e} des Arm{\'e}es (PDH-2-NRBC-4-B2-408), and the ARAMI association. This work used the platforms of the Grenoble ERIC-Instruct Center (ISBG; UMS 3518 CNRS-CEA-UGA-EMBL) with support from FRISBI (ANR-10-INSB-05-02) and GRAL (ANR-10-LABX-49-01) within the Grenoble Partnership for Structural Biology (PSB). O.R. and V.V. are supported by the Institut national de la sant{\'e} et de la recherche m{\'e}dicale (INSERM), Agence Nationale de la Recherche (ANR-14-EBOL-0002-01). Funding Information: Funding: We acknowledge the support of the Direction G{\'e}n{\'e}rale pour l{\textquoteright}Armement (DGA), the Service de Sant{\'e} des Arm{\'e}es (PDH-2-NRBC-4-B2-408), and the ARAMI association. This work used the platforms of the Grenoble ERIC-Instruct Center (ISBG; UMS 3518 CNRS-CEA-UGA-EMBL) with support from FRISBI (ANR-10-INSB-05-02) and GRAL (ANR-10-LABX-49-01) within the Grenoble Partnership for Structural Biology (PSB). O.R. and V.V. are supported by the Institut national de la sant{\'e} et de la recherche m{\'e}dicale (INSERM), Agence Nationale de la Recherche (ANR-14-EBOL-0002-01). Publisher Copyright: {\textcopyright} 2018 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2019",
month = jan,
doi = "10.3390/v11010015",
language = "English",
volume = "11",
journal = "Viruses",
issn = "1999-4915",
number = "1",
}