Involvement of intestinal alkaline phosphatase in serum apolipoprotein B-48 level and its association with ABO and secretor blood group types

Takanari Nakano, Tomoko Shimanuki, Makoto Matsushita, Iwao Koyama, Ikuo Inoue, Shigehiro Katayama, David H. Alpers, Tsugikazu Komoda

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Serum levels of intestinal alkaline phosphatase (IAP), a protein implicated in transcellular transport of chylomicrons, vary among ABO blood groups. In rat enterocytes, IAP is associated with chylomicron secretion, but the rat expresses only blood group A. It is not known whether chylomicron secretion may be affected in humans who express multiple blood group types. Serum samples from 40 healthy subjects were obtained after overnight fast and 3 h after a high-fat meal, and assayed for IAP and apolipoprotein B-48 (apoB-48), both proteins exclusive to intestine, although only apoB-48 is found in chylomicrons. The two proteins were greater in subjects without blood antigen A (B and O) than in those with this antigen (A and AB); 2.4- and 4.7-fold for IAP and 1.5- and 2.0-fold for apoB-48 before and after the meal, respectively. Moreover, IAP and apoB-48 levels were strongly correlated in the subjects with the secretor phenotype (r > 0.81). These results indicate that IAP is strongly involved in chylomicron formation and fatty acid metabolism might change among ABO blood type. In addition, ABO blood type classification in apoB-48 measurement would improve the diagnostic value in the evaluation of metabolic syndrome.

Original languageEnglish
Pages (from-to)33-38
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume341
Issue number1
DOIs
StatePublished - Mar 3 2006

Keywords

  • ABO blood group
  • Apolipoprotein B-48
  • Chylomicron
  • Intestinal alkaline phosphatase
  • Secretor phenotype
  • Triglyceride

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