Involvement of E-cadherin in thymus organogenesis and thymocyte maturation

Kai M. Müller, Carrie J. Luedecker, Mark C. Udey, Andrew G. Farr

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

We examined the role of E-cadherin expressed by thymic epithelial cells and immature thymocytes in thymus organogenesis and thymocyte development. ECCD-1 MAb, which blocks homotypic E-cadherin interactions, inhibited epithelial organization and thymocyte development in reaggregate fetal thymic organ cultures. It also interfered with the differentiation of fetal liver cells or fetal thymocytes within deoxyguanosine-treated thymic lobes, but did not affect thymocyte development in intact cultured fetal thymic lobes. In contrast, antibodies that selectively inhibit interactions between E-cadherin and α(E)β7 integrins did not perturb thymic epithelial organization or thymocyte development, suggesting that homotypic E-cadherin interactions play an important role in thymus development and function.

Original languageEnglish
Pages (from-to)257-264
Number of pages8
JournalImmunity
Volume6
Issue number3
DOIs
StatePublished - Mar 1997

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