TY - JOUR
T1 - Involvement of arabidopsis histone acetyltransferase HAC family genes in the ethylene signaling pathway
AU - Li, Chao
AU - Xu, Jiang
AU - Li, Jian
AU - Li, Qingyun
AU - Yang, Hongchun
N1 - Funding Information:
We thank the Arabidopsis BiologicalResources Center at the Ohio StateUniversity and Bernd Weisshaar forproviding SALK and GABI T-DNAinsertion lines in the Col-0 background. This work was supported by the Ministry of Science and Technology of China 863 project, Transgenic Program of China (2009ZX08009–065B), and the National Natural Science Foundation of China (31071351).
PY - 2014/2
Y1 - 2014/2
N2 - Epigenetic modifications play a fundamental role in regulating chromatin dynamics and gene expression. The level of histone acetylation is controlled by two functionally antagonistic enzymes, namely histone acetyltransferase (HAT) and histone deacetylase (HDAC). CREB-binding protein (CBP)/p300 proteins, a subfamily of highly conserved HATs, are involved in various physiological events including proliferation, differentiation and apoptosis. In this work, we study the poorly known function of their homologous genes, the HAC genes, in Arabidopsis. We found that hac1-involved mutants displayed pleiotropic phenotypes, in particular hypersensitivity to ethylene both in the dark and in the light. We also found that the transcriptional levels of ethylene-responsive genes are significantly higher in the hac1hac5 double mutant than in wild-type plants. Moreover, an ethylene synthesis inhibitor cannot release the triple responses of hac mutants. These results suggest that HACs are involved in the ethylene signaling pathway.
AB - Epigenetic modifications play a fundamental role in regulating chromatin dynamics and gene expression. The level of histone acetylation is controlled by two functionally antagonistic enzymes, namely histone acetyltransferase (HAT) and histone deacetylase (HDAC). CREB-binding protein (CBP)/p300 proteins, a subfamily of highly conserved HATs, are involved in various physiological events including proliferation, differentiation and apoptosis. In this work, we study the poorly known function of their homologous genes, the HAC genes, in Arabidopsis. We found that hac1-involved mutants displayed pleiotropic phenotypes, in particular hypersensitivity to ethylene both in the dark and in the light. We also found that the transcriptional levels of ethylene-responsive genes are significantly higher in the hac1hac5 double mutant than in wild-type plants. Moreover, an ethylene synthesis inhibitor cannot release the triple responses of hac mutants. These results suggest that HACs are involved in the ethylene signaling pathway.
KW - HAC family genes
KW - Histone acetyltransferase
UR - http://www.scopus.com/inward/record.url?scp=84893843333&partnerID=8YFLogxK
U2 - 10.1093/pcp/pct180
DO - 10.1093/pcp/pct180
M3 - Article
C2 - 24287137
AN - SCOPUS:84893843333
SN - 0032-0781
VL - 55
SP - 426
EP - 435
JO - Plant and Cell Physiology
JF - Plant and Cell Physiology
IS - 2
ER -