TY - GEN
T1 - Investigation of breast cancer detectability using PET insert with whole-body and zoom-in imaging capability
AU - Mathews, Aswin John
AU - Komarov, Sergey
AU - Kume, Maiko
AU - Wu, Heyu
AU - O'Sullivan, Joseph A.
AU - Tai, Yuan Chuan
PY - 2011
Y1 - 2011
N2 - Traditional whole-body PET scanner is limited in resolution due to large detector crystal size, finite positron range and non-collinearity of annihilation photons. Our lab has developed a prototype half ring insert PET system that can improve resolution and radionuclide contrast recovery by using (1) smaller size of the detector crystals (2) virtual pinhole PET geometry obtained by placing the insert close to the imaging subject. This design allows for zooming-in to an area of interest while still maintaining the scanners whole-body imaging capability. To find the limits of the image resolution and contrast recovery, we performed a set of Monte Carlo simulations for a clinical PET system with and without half ring insert. The reconstructed images show the improvement in image resolution, with 3 mm diameter tumors resolvable with insert at a contrast ratio of 91, compared to scanner without insert where smallest tumors resolvable was 6 mm.
AB - Traditional whole-body PET scanner is limited in resolution due to large detector crystal size, finite positron range and non-collinearity of annihilation photons. Our lab has developed a prototype half ring insert PET system that can improve resolution and radionuclide contrast recovery by using (1) smaller size of the detector crystals (2) virtual pinhole PET geometry obtained by placing the insert close to the imaging subject. This design allows for zooming-in to an area of interest while still maintaining the scanners whole-body imaging capability. To find the limits of the image resolution and contrast recovery, we performed a set of Monte Carlo simulations for a clinical PET system with and without half ring insert. The reconstructed images show the improvement in image resolution, with 3 mm diameter tumors resolvable with insert at a contrast ratio of 91, compared to scanner without insert where smallest tumors resolvable was 6 mm.
KW - Monte Carlo methods
KW - Positron emission tomography
KW - Reconstruction algorithms
UR - http://www.scopus.com/inward/record.url?scp=80055033572&partnerID=8YFLogxK
U2 - 10.1109/ISBI.2011.5872752
DO - 10.1109/ISBI.2011.5872752
M3 - Conference contribution
AN - SCOPUS:80055033572
SN - 9781424441280
T3 - Proceedings - International Symposium on Biomedical Imaging
SP - 1784
EP - 1787
BT - 2011 8th IEEE International Symposium on Biomedical Imaging
T2 - 2011 8th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI'11
Y2 - 30 March 2011 through 2 April 2011
ER -