Investigating trends in those who experience menstrual bleeding changes after SARS-CoV-2 vaccination

Katharine M.N. Lee, Eleanor J. Junkins, Chongliang Luo, Urooba A. Fatima, Maria L. Cox, Kathryn B.H. Clancy

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


Early in 2021, many people began sharing that they experienced unexpected menstrual bleeding after SARSCoV-2 inoculation. We investigated this emerging phenomenon of changed menstrual bleeding patterns among a convenience sample of currently and formerly menstruating people using a web-based survey. In this sample, 42% of people with regular menstrual cycles bled more heavily than usual, while 44% reported no change after being vaccinated. Among respondents who typically do not menstruate, 71% of people on long-acting reversible contraceptives, 39% of people on gender-affirming hormones, and 66% of postmenopausal people reported breakthrough bleeding. We found that increased/breakthrough bleeding was significantly associated with age, systemic vaccine side effects (fever and/or fatigue), history of pregnancy or birth, and ethnicity. Generally, changes to menstrual bleeding are not uncommon or dangerous, yet attention to these experiences is necessary to build trust in medicine.

Original languageEnglish
Article numbereabm7201
JournalScience Advances
Issue number28
StatePublished - Jul 2022


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