TY - JOUR
T1 - Investigating neutron activated contrast agent imaging for tumor localization in proton therapy
T2 - A feasibility study for proton neutron gamma-x detection (PNGXD)
AU - Van Delinder, Kurt W.
AU - Crawford, Daniel
AU - Zhang, Tiezhi
AU - Khan, Rao
AU - Grafe, James L.
N1 - Publisher Copyright:
© 2020 Institute of Physics and Engineering in Medicine.
PY - 2020/1/24
Y1 - 2020/1/24
N2 - Proton neutron gamma-x detection (PNGXD) is a novel imaging concept being investigated for tumor localization during proton therapy that uses secondary neutron interactions with a gadolinium contrast agent (GDCA) to produce characteristic photons within the 40-200 keV energy region. The purpose of this study is to experimentally investigate the feasibility of implementing this procedure by performing experimental measurements on a passive double scattering proton treatment unit. Five experimental measurements were performed with varying concentrations and irradiation conditions. Photon spectra were measured with a 25 mm2, 1 mm thick uncollimated X-123 CdTe spectrometer. For a 10.4 Gy administration on a 100 ml volume phantom with 10 mg g-1 Gd solution placed in a water phantom, 1129 184 K-shell Gd counts were detected. For an administered dose of 21 Gy and the same Gd solution measured in air, resulted in 3296 256 counts. A total of 1094 171, 421 150 and 23 141 K-shell Gd counts were measured for Gd concentrations of 10 mg g-1, 1 mg g-1 and 0 mg g-1 for 7 Gy dose in air. The signal to noise ratio for these five measurements were: 7, 15, 6, 3, and 0.2, respectively. The spectrum contained 43 keV Kα and 49 keV Kβ peaks, however a small amount of 79.5 and 181.9 keV prompt gamma rays were detected from gadolinium neutron capture. This discrepancy is due to a drop in the intrinsic detection efficiency of the CdTe spectrometer over this energy range. The measurements were compared with Monte-Carlo simulation to determine the contributions of Gd neutron capture from internal and external neutrons on a passive scattering proton therapy unit and to investigate the discrepancy in detected characteristic x-rays versus prompt gamma rays.
AB - Proton neutron gamma-x detection (PNGXD) is a novel imaging concept being investigated for tumor localization during proton therapy that uses secondary neutron interactions with a gadolinium contrast agent (GDCA) to produce characteristic photons within the 40-200 keV energy region. The purpose of this study is to experimentally investigate the feasibility of implementing this procedure by performing experimental measurements on a passive double scattering proton treatment unit. Five experimental measurements were performed with varying concentrations and irradiation conditions. Photon spectra were measured with a 25 mm2, 1 mm thick uncollimated X-123 CdTe spectrometer. For a 10.4 Gy administration on a 100 ml volume phantom with 10 mg g-1 Gd solution placed in a water phantom, 1129 184 K-shell Gd counts were detected. For an administered dose of 21 Gy and the same Gd solution measured in air, resulted in 3296 256 counts. A total of 1094 171, 421 150 and 23 141 K-shell Gd counts were measured for Gd concentrations of 10 mg g-1, 1 mg g-1 and 0 mg g-1 for 7 Gy dose in air. The signal to noise ratio for these five measurements were: 7, 15, 6, 3, and 0.2, respectively. The spectrum contained 43 keV Kα and 49 keV Kβ peaks, however a small amount of 79.5 and 181.9 keV prompt gamma rays were detected from gadolinium neutron capture. This discrepancy is due to a drop in the intrinsic detection efficiency of the CdTe spectrometer over this energy range. The measurements were compared with Monte-Carlo simulation to determine the contributions of Gd neutron capture from internal and external neutrons on a passive scattering proton therapy unit and to investigate the discrepancy in detected characteristic x-rays versus prompt gamma rays.
KW - Monte Carlo simulation
KW - gadolinium neutron capture
KW - particle imaging
KW - proton neutron gamma detection
KW - proton therapy
KW - spectroscopy
UR - http://www.scopus.com/inward/record.url?scp=85078560910&partnerID=8YFLogxK
U2 - 10.1088/1361-6560/ab63b5
DO - 10.1088/1361-6560/ab63b5
M3 - Article
C2 - 31851952
AN - SCOPUS:85078560910
SN - 0031-9155
VL - 65
JO - Physics in medicine and biology
JF - Physics in medicine and biology
IS - 3
M1 - 035005
ER -