Investigating Basal Ganglia Function With Cell-Type-Specific Manipulations

A. V. Kravitz, K. Devarakonda, A. C. Kreitzer

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Over the past two decades, there has been an explosion of tools that allow researchers to manipulate and observe the function of specific neural populations and their projections. These tools, including optogenetics, chemogenetics, cell-type-specific ablation, and fluorescent calcium indicators, have been especially useful in studying the function of cell types in the basal ganglia, where the majority of neurons are essentially indistinguishable by morphology or physiology. Although recent work has mostly supported the classical model of basal ganglia structure and function, cell-type-specific methods have revealed nuances in the role of striatal circuits in reward and action selection. These tools have also provided evidence for an expanded role of the basal ganglia in reinforcement and emotional states. Moving forward, new technologies will be needed to study the basal ganglia on a circuit level to better understand how cell types interact to shape behavior.

Original languageEnglish
Title of host publicationHandbook of Behavioral Neuroscience
PublisherElsevier B.V.
Pages689-706
Number of pages18
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

Publication series

NameHandbook of Behavioral Neuroscience
Volume24
ISSN (Print)1569-7339

Keywords

  • Basal ganglia
  • calcium imaging
  • cell-type-specific
  • chemogenetics
  • optogenetics
  • striatal circuits

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    Kravitz, A. V., Devarakonda, K., & Kreitzer, A. C. (2016). Investigating Basal Ganglia Function With Cell-Type-Specific Manipulations. In Handbook of Behavioral Neuroscience (pp. 689-706). (Handbook of Behavioral Neuroscience; Vol. 24). Elsevier B.V.. https://doi.org/10.1016/B978-0-12-802206-1.00033-7