Inverse susceptibility to oxidative death of lymphocytes obtained from Alzheimer's patients and skin cancer survivors: Increased apoptosis in Alzheimer's and reduced necrosis in cancer

Maria I. Behrens, Monica Silva, Felipe Salech, Daniela P. Ponce, Daniela Merino, Mariana Sinning, Chengjie Xiong, Catherine M. Roe, Andrew F.G. Quest

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

A paucity of cancer in individuals with Alzheimer's disease (AD) and low rates of AD in cancer survivors has been reported in epidemiological studies. Deregulation in opposite directions of biological mechanisms, such as susceptibility to cell death, might be shared in the two disorders. We analyzed lymphocytes from AD and skin cancer patients as well as healthy controls and found significantly increased vulnerability of AD lymphocytes to H2O2-induced apoptotic death and higher resistance to death of skin cancer lymphocytes, due to reduced necrosis, as compared with healthy controls by pairwise comparisons adjusted for age and sex. H2O2-induced death in lymphocytes was caspase independent and significantly reduced by PARP-1 inhibition in all three groups. These differences in the susceptibility to cell death observed for lymphocytes from AD and skin cancer patients may be one of the mechanisms that help explain the inverse correlation detected between these diseases in epidemiological studies.

Original languageEnglish
Pages (from-to)1036-1040
Number of pages5
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume67 A
Issue number10
DOIs
StatePublished - Oct 2012

Keywords

  • Alzheimer
  • Apoptosis
  • Cancer
  • Cell death
  • Necrosis

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