TY - JOUR
T1 - Invasive fungal rhinosinusitis
T2 - current evidence and research opportunities
AU - Ji, Jenny
AU - Roland, Lauren T.
N1 - Publisher Copyright:
Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2025/2/1
Y1 - 2025/2/1
N2 - Purpose of review: To summarize the evidence surrounding diagnosis, treatment, prognosis, and surveillance of patients with acute invasive fungal sinusitis (AIFS) and discuss future research needs. Recent findings: New risk factors for AIFS such as COVID have been identified, and a new prognostic staging system has been developed. Summary: Most patients who develop AIFS are immunocompromised, with the majority having a history of diabetes or a hematologic malignancy. Unfortunately, there are not any highly sensitive and specific diagnostic tools. Therefore, a combination of signs and symptoms, imaging, endoscopy, biopsy, and labs should be used to diagnosis AIFS. Although surgery and systemic antifungals are known to improve outcomes, there is limited data on time to intervention, duration of antifungals, and surveillance patterns. There is also limited information on factors that can predict outcomes in AIFS patients. However, sensory/perceptual changes, prolonged neutropenia duration, and comorbidity burden may be associated with a poor prognosis.
AB - Purpose of review: To summarize the evidence surrounding diagnosis, treatment, prognosis, and surveillance of patients with acute invasive fungal sinusitis (AIFS) and discuss future research needs. Recent findings: New risk factors for AIFS such as COVID have been identified, and a new prognostic staging system has been developed. Summary: Most patients who develop AIFS are immunocompromised, with the majority having a history of diabetes or a hematologic malignancy. Unfortunately, there are not any highly sensitive and specific diagnostic tools. Therefore, a combination of signs and symptoms, imaging, endoscopy, biopsy, and labs should be used to diagnosis AIFS. Although surgery and systemic antifungals are known to improve outcomes, there is limited data on time to intervention, duration of antifungals, and surveillance patterns. There is also limited information on factors that can predict outcomes in AIFS patients. However, sensory/perceptual changes, prolonged neutropenia duration, and comorbidity burden may be associated with a poor prognosis.
KW - diagnosis
KW - invasive fungal sinusitis
KW - recommendations
KW - treatment
UR - http://www.scopus.com/inward/record.url?scp=85202049008&partnerID=8YFLogxK
U2 - 10.1097/MOO.0000000000000993
DO - 10.1097/MOO.0000000000000993
M3 - Review article
C2 - 39146258
AN - SCOPUS:85202049008
SN - 1068-9508
VL - 33
SP - 20
EP - 30
JO - Current Opinion in Otolaryngology and Head and Neck Surgery
JF - Current Opinion in Otolaryngology and Head and Neck Surgery
IS - 1
ER -