TY - JOUR
T1 - Invasive fungal infections
T2 - Cryptococcosis
AU - Mundy, Linda M.
AU - Powderly, William G.
PY - 1997/5
Y1 - 1997/5
N2 - The clinical sequelae of host exposure to Cryptococcus neoformans ranges from pulmonary colonization to disseminated invasive fungal disease. After inhalation, the interaction of the host immune status, size of the inoculum, and virulence of the yeast potentially establish or thwart clinical disease. With the rising prevalence of patients with HIV infection, our understanding of the immunopathogenesis of C. neoformans has greatly expanded. We review the current appreciation of host-yeast pathogenesis, along with the diagnostic work-up, treatment, and prevention strategies of cryptococcosis.
AB - The clinical sequelae of host exposure to Cryptococcus neoformans ranges from pulmonary colonization to disseminated invasive fungal disease. After inhalation, the interaction of the host immune status, size of the inoculum, and virulence of the yeast potentially establish or thwart clinical disease. With the rising prevalence of patients with HIV infection, our understanding of the immunopathogenesis of C. neoformans has greatly expanded. We review the current appreciation of host-yeast pathogenesis, along with the diagnostic work-up, treatment, and prevention strategies of cryptococcosis.
KW - Cryptococcosis
KW - Prophylaxis
KW - Treatment
KW - Virulence
UR - http://www.scopus.com/inward/record.url?scp=0030789365&partnerID=8YFLogxK
U2 - 10.1055/s-2008-1070994
DO - 10.1055/s-2008-1070994
M3 - Article
AN - SCOPUS:0030789365
SN - 1069-3424
VL - 18
SP - 249
EP - 257
JO - Seminars in Respiratory and Critical Care Medicine
JF - Seminars in Respiratory and Critical Care Medicine
IS - 3
ER -