TY - JOUR
T1 - Invasive Ductal Carcinoma in a 46,XY Partial Androgen Insensitivity Syndrome Patient on Hormone Therapy
AU - Hoefgen, Holly R.
AU - Merritt, Diane F.
N1 - Publisher Copyright:
© 2015 North American Society for Pediatric and Adolescent Gynecology.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Background: The hormonal management of patients with androgen insensitivity can be challenging. Case: An illustrative case is presented of a newborn with ambiguous genitalia who was raised female. She was diagnosed as 46,XY Disorder of Sexual Development with partial androgen insensitivity. To induce puberty, conjugated equine estrogens were administered beginning at age 12. At age 13, she instead began taking combined oral contraceptives for maternal concerns about height and continued taking them for social reasons. Invasive ductal carcinoma was diagnosed at age 27, and the patient was treated with chemotherapy, radiation therapy, bilateral mastectomies, and endocrine therapy. Summary and Conclusion: The current literature is reviewed, and hormonal management and other risks for breast cancer are discussed.
AB - Background: The hormonal management of patients with androgen insensitivity can be challenging. Case: An illustrative case is presented of a newborn with ambiguous genitalia who was raised female. She was diagnosed as 46,XY Disorder of Sexual Development with partial androgen insensitivity. To induce puberty, conjugated equine estrogens were administered beginning at age 12. At age 13, she instead began taking combined oral contraceptives for maternal concerns about height and continued taking them for social reasons. Invasive ductal carcinoma was diagnosed at age 27, and the patient was treated with chemotherapy, radiation therapy, bilateral mastectomies, and endocrine therapy. Summary and Conclusion: The current literature is reviewed, and hormonal management and other risks for breast cancer are discussed.
KW - 46,XY disorders of sexual development
KW - Androgen insensitivity syndrome
KW - Breast Neoplasms
UR - http://www.scopus.com/inward/record.url?scp=84932196048&partnerID=8YFLogxK
U2 - 10.1016/j.jpag.2014.08.005
DO - 10.1016/j.jpag.2014.08.005
M3 - Article
C2 - 26024935
AN - SCOPUS:84932196048
SN - 1083-3188
VL - 28
SP - e95-e97
JO - Journal of Pediatric and Adolescent Gynecology
JF - Journal of Pediatric and Adolescent Gynecology
IS - 4
ER -