Invasion of vertebrate cells by Toxoplasma gondii

L. David Sibley

doi:10.1016/S0962-8924(00)88964-3

Invasion of vertebrate cells by Toxoplasma gondii

L. David Sibley

Research output: Contribution to journal › Review article › peer-review

62 Scopus citations

Abstract

Toxoplasma gondii actively invades its host cell rather than entering by conventional phagocytosis. Invasion is powered by a micro filament-based motility system in the parasite that leads to invagination of the host cell plasma membrane to form a novel intracellular vacuole. This vacuole resists fusion with the endocytic network of the host cell and provides a protective environment for replication o f the parasite.

Original language	English
Pages (from-to)	129-132
Number of pages	4
Journal	Trends in Cell Biology
Volume	5
Issue number	3
DOIs	https://doi.org/10.1016/S0962-8924(00)88964-3
State	Published - Mar 1995

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10.1016/S0962-8924(00)88964-3

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title = "Invasion of vertebrate cells by Toxoplasma gondii",

abstract = "Toxoplasma gondii actively invades its host cell rather than entering by conventional phagocytosis. Invasion is powered by a micro filament-based motility system in the parasite that leads to invagination of the host cell plasma membrane to form a novel intracellular vacuole. This vacuole resists fusion with the endocytic network of the host cell and provides a protective environment for replication o f the parasite.",

author = "Sibley, {L. David}",

note = "Funding Information: I thank John Heuser, David Russell, Phil Stahl, Joel Swanson, Tom Steinberg and Gay Ward for valuable discussions and comments. The work in my laboratory is supported by the NIH and the Burroughs Wellcome Fund.",

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PY - 1995/3

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N2 - Toxoplasma gondii actively invades its host cell rather than entering by conventional phagocytosis. Invasion is powered by a micro filament-based motility system in the parasite that leads to invagination of the host cell plasma membrane to form a novel intracellular vacuole. This vacuole resists fusion with the endocytic network of the host cell and provides a protective environment for replication o f the parasite.

AB - Toxoplasma gondii actively invades its host cell rather than entering by conventional phagocytosis. Invasion is powered by a micro filament-based motility system in the parasite that leads to invagination of the host cell plasma membrane to form a novel intracellular vacuole. This vacuole resists fusion with the endocytic network of the host cell and provides a protective environment for replication o f the parasite.

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DO - 10.1016/S0962-8924(00)88964-3

M3 - Review article

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JF - Trends in Cell Biology

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Invasion of vertebrate cells by Toxoplasma gondii

Abstract

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