@article{6d45be91782c4a16a5251b6752da1bdd,
title = "Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals",
abstract = "Invariant natural killer T cells (iNKT cells) have a prominent role during infection and other inflammatory processes, and these cells can be activated through their T cell antigen receptors by microbial lipid antigens. However, increasing evidence shows that they are also activated in situations in which foreign lipid antigens would not be present, which suggests a role for lipid self antigen. We found that an abundant endogenous lipid, β-D- glucopyranosylceramide (β-GlcCer), was a potent iNKT cell self antigen in mouse and human and that its activity depended on the composition of the N-acyl chain. Furthermore, β-GlcCer accumulated during infection and in response to Toll-like receptor agonists, contributing to iNKT cell activation. Thus, we propose that recognition of β-GlcCer by the invariant T cell antigen receptor translates innate danger signals into iNKT cell activation.",
author = "Brennan, {Patrick J.} and Tatituri, {Raju V.V.} and Manfred Brigl and Kim, {Edy Y.} and Amit Tuli and Sanderson, {Joseph P.} and Gadola, {Stephan D.} and Hsu, {Fong Fu} and Besra, {Gurdyal S.} and Brenner, {Michael B.}",
note = "Funding Information: We thank M. Exley (Beth Israel Deaconess Medical Center) for Cd1d−/− mice on a C57BL/6 background; K. Kawakami (Tohoku University) for S.pneumoniae (stain URF918); H. Kim for assistance with flow cytometry; and the tetramer facility of the US National Institutes of Health for ongoing support. Supported by the US National Institutes of Health (R01AI063428; T32AI007306 to P.J.B.; T32HL007633 to E.Y.K.; K08AI077795 to M.B.; P41-RR00954, P30-DK56341 and P60-DK20579 to F.-F.H.; and P41-RR05351 (Research Resource for Integrated Glycotechnology) to P. Azadi at the Complex Carbohydrate Research Center for nuclear magnetic resonance spectroscopy analysis), the Higher Education Funding Council for England (S.D.G. and J.P.S.), J. Bardrick (G.S.B.), the Royal Society (G.S.B.), the Medical Research Council (G.S.B.) and The Wellcome Trust (084923/B/08/Z to G.S.B.).",
year = "2011",
month = dec,
doi = "10.1038/ni.2143",
language = "English",
volume = "12",
pages = "1202--1211",
journal = "Nature Immunology",
issn = "1529-2908",
number = "12",
}