Posttransplant lymphoproliferative disorders (PTLDs) straddle the disciplines of immunology, infection, and malignancy. PTLDs are a major complication of transplantation, such that its study is a discipline by itself. The study of PTLD has led to advances that have ramifications beyond transplantation. Early observations revealed that lightening of immunosuppression could lead to regression in some cases, eliminating the hopelessness of the word "lymphoma." While PTLD treatments and outcomes have improved, responses remain suboptimal, and the need for additional strategies for prevention and treatment remains.
- B cell
- Epstein-Barr virus
- Posttransplant lymphoproliferative disorder