Intrinsic properties and regulation of Pannexin 1 channel

Yu Hsin Chiu, Kodi S. Ravichandran, Douglas A. Bayliss

Research output: Contribution to journalReview articlepeer-review

50 Scopus citations

Abstract

Pannexin 1 (Panx1) channels are generally represented as non-selective, large-pore channels that release ATP. Emerging roles have been described for Panx1 in mediating purinergic signaling in the normal nervous, cardiovascular, and immune systems, where they may be activated by mechanical stress, ionotropic and metabotropic receptor signaling, and via proteolytic cleavage of the Panx1 C-terminus. Panx1 channels are widely expressed in various cell types, and it is now thought that targeting these channels therapeutically may be beneficial in a number of pathophysiological contexts, such as asthma, atherosclerosis, hypertension, and ischemic-induced seizures. Even as interest in Panx1 channels is burgeoning, some of their basic properties, mechanisms of modulation, and proposed functions remain controversial, with recent reports challenging some long-held views regarding Panx1 channels. In this brief review, we summarize some well-established features of Panx1 channels; we then address some current confounding issues surrounding Panx1 channels, especially with respect to intrinsic channel properties, in order to raise awareness of these unsettled issues for future research.

Original languageEnglish
Pages (from-to)103-109
Number of pages7
JournalChannels
Volume8
Issue number2
DOIs
StatePublished - 2014

Keywords

  • ATP release
  • Ionic selectivity
  • P2X receptor
  • Pannexin 1
  • Unitary conductance

Fingerprint

Dive into the research topics of 'Intrinsic properties and regulation of Pannexin 1 channel'. Together they form a unique fingerprint.

Cite this