TY - JOUR
T1 - Intrinsic network connectivity abnormalities in HIV-infected individuals over age 60
AU - Guha, Anika
AU - Wang, Liang
AU - Tanenbaum, Aaron
AU - Esmaeili-Firidouni, Pardis
AU - Wendelken, Lauren A.
AU - Busovaca, Edgar
AU - Clifford, Katherine
AU - Desai, Akash
AU - Ances, Beau M.
AU - Valcour, Victor
N1 - Funding Information:
We thank our study participants. We also thank Hannah Jang, Robin Ketelle, Katherine Rankin, and Stephanie Chiao for their involvement in the HIV Over 60 Cohort. This work was funded by the National Institute of Health Grants K23-AG032872 (VV), R01-NR012907 (BMA), R01-NR012657 (BMA), and R01-NR014449 (BMA); the Larry L. Hillblom Foundation (VV), the UCSF/GIVI Center For AIDS Research, and the UCSF AIDS Research Institute. Additional support from the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health, through UCSF-CTSI Grant Number UL1 RR024131.
Publisher Copyright:
© 2015, Journal of NeuroVirology, Inc.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Individuals infected with HIV are living longer due to effective treatment with combination antiretroviral therapy (cART). Despite these advances, HIV-associated neurocognitive disorders (HAND) remain prevalent. In this study, we analyzed resting state functional connectivity (rs-fc) data from HIV-infected and matched HIV-uninfected adults aged 60 years and older to determine associations between HIV status, neuropsychological performance, and clinical variables. HIV-infected participants with detectable plasma HIV RNA exhibited decreased rs-fc within the salience (SAL) network compared to HIV-infected participants with suppressed plasma HIV RNA. We did not identify differences in rs-fc within HIV-infected individuals by HAND status. Our analysis identifies focal deficits in the SAL network that may be mitigated with suppression of plasma virus. However, these findings suggest that rs-fc may not be sensitive as a marker of HAND among individuals with suppressed plasma viral loads.
AB - Individuals infected with HIV are living longer due to effective treatment with combination antiretroviral therapy (cART). Despite these advances, HIV-associated neurocognitive disorders (HAND) remain prevalent. In this study, we analyzed resting state functional connectivity (rs-fc) data from HIV-infected and matched HIV-uninfected adults aged 60 years and older to determine associations between HIV status, neuropsychological performance, and clinical variables. HIV-infected participants with detectable plasma HIV RNA exhibited decreased rs-fc within the salience (SAL) network compared to HIV-infected participants with suppressed plasma HIV RNA. We did not identify differences in rs-fc within HIV-infected individuals by HAND status. Our analysis identifies focal deficits in the SAL network that may be mitigated with suppression of plasma virus. However, these findings suggest that rs-fc may not be sensitive as a marker of HAND among individuals with suppressed plasma viral loads.
KW - Cognition
KW - Functional MRI
KW - HIV
KW - Network connectivity
UR - http://www.scopus.com/inward/record.url?scp=84957849991&partnerID=8YFLogxK
U2 - 10.1007/s13365-015-0370-y
DO - 10.1007/s13365-015-0370-y
M3 - Article
C2 - 26265137
AN - SCOPUS:84957849991
SN - 1355-0284
VL - 22
SP - 80
EP - 87
JO - Journal of NeuroVirology
JF - Journal of NeuroVirology
IS - 1
ER -