Intrinsic network connectivity abnormalities in HIV-infected individuals over age 60

Anika Guha, Liang Wang, Aaron Tanenbaum, Pardis Esmaeili-Firidouni, Lauren A. Wendelken, Edgar Busovaca, Katherine Clifford, Akash Desai, Beau M. Ances, Victor Valcour

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Individuals infected with HIV are living longer due to effective treatment with combination antiretroviral therapy (cART). Despite these advances, HIV-associated neurocognitive disorders (HAND) remain prevalent. In this study, we analyzed resting state functional connectivity (rs-fc) data from HIV-infected and matched HIV-uninfected adults aged 60 years and older to determine associations between HIV status, neuropsychological performance, and clinical variables. HIV-infected participants with detectable plasma HIV RNA exhibited decreased rs-fc within the salience (SAL) network compared to HIV-infected participants with suppressed plasma HIV RNA. We did not identify differences in rs-fc within HIV-infected individuals by HAND status. Our analysis identifies focal deficits in the SAL network that may be mitigated with suppression of plasma virus. However, these findings suggest that rs-fc may not be sensitive as a marker of HAND among individuals with suppressed plasma viral loads.

Original languageEnglish
Pages (from-to)80-87
Number of pages8
JournalJournal of NeuroVirology
Issue number1
StatePublished - Feb 1 2016


  • Cognition
  • Functional MRI
  • HIV
  • Network connectivity


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