Intrinsic laryngeal muscle reinnervation using the muscle-nerve-muscle technique

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Objectives: This study was performed to investigate the muscle-nerve-muscle reinnervation technique in the larynx, in which a nerve conduit implanted into an innervated muscle conducts axonal sprouting into a denervated muscle while maintaining function of the donor muscle. Methods: In this study, the muscle-nerve-muscle technique was used to direct superior laryngeal nerve axons to reinnervate intrinsic laryngeal muscles by implanting the recurrent laryngeal nerve stump into the cricothyroid muscle in 8 dogs. In 4 of the dogs, the recurrent laryngeal nerve trunk to the adductor muscles was divided so that all axonal sprouting was directed to the posterior cricoarytenoid muscle. Six-month electromyography data were obtained from 6 of the 8 dogs. Results: All 6 dogs showed evidence of successful reinnervation of the thyroarytenoid or posterior cricoarytenoid muscles with action potentials that corresponded to spontaneous respiratory efforts, while the donor cricothyroid muscles retained their phasic contraction. These responses were obliterated when the recurrent laryngeal nerve conduit was divided. Histologic examination of the intrinsic laryngeal muscles demonstrated successful reinnervation. Conclusions: The results confirm that intrinsic laryngeal muscles may be successfully reinnervated by the superior laryngeal nerve with the muscle-nerve-muscle technique, without sacrifice of function of the cricothyroid muscle. This method offers an alternative source of appropriately firing axons for laryngeal reinnervation procedures.

Original languageEnglish
Pages (from-to)382-388
Number of pages7
JournalAnnals of Otology, Rhinology and Laryngology
Volume117
Issue number5
DOIs
StatePublished - May 2008

Keywords

  • Dog
  • Larynx
  • Nerve
  • Reinnervation
  • Vocal cord paralysis

Fingerprint Dive into the research topics of 'Intrinsic laryngeal muscle reinnervation using the muscle-nerve-muscle technique'. Together they form a unique fingerprint.

  • Cite this