Intrinsic foot muscle deterioration is associated with metatarsophalangeal joint angle in people with diabetes and neuropathy

Victor A. Cheuy, Mary K. Hastings, Paul K. Commean, Samuel R. Ward, Michael J. Mueller

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Background Metatarsophalangeal joint deformity is associated with skin breakdown and amputation. The aims of this study were to compare intrinsic foot muscle deterioration ratios (ratio of adipose to muscle volume), and physical performance in subjects with diabetic neuropathy to controls, and determine their associations with 1) metatarsophalangeal joint angle and 2) history of foot ulcer. Methods 23 diabetic, neuropathic subjects [59 (SD 10) years] and 12 age-matched controls [57 (SD 14) years] were studied. Radiographs and MRI were used to measure metatarsophalangeal joint angle and intrinsic foot muscle deterioration through tissue segmentation by image signal intensity. The Foot and Ankle Ability Measure evaluated physical performance. Findings The diabetic, neuropathic group had a higher muscle deterioration ratio [1.6 (SD 1.2) vs. 0.3 (SD 0.2), P < 0.001], and lower Foot and Ankle Ability Measure scores [65.1 (SD 24.4) vs. 98.3 (SD 3.3) %, P < 0.01]. The correlation between muscle deterioration ratio and metatarsophalangeal joint angle was r = - 0.51 (P = 0.01) for all diabetic, neuropathic subjects, but increased to r = - 0.81 (P < 0.01) when only subjects with muscle deterioration ratios > 1.0 were included. Muscle deterioration ratios in individuals with diabetic neuropathy were higher for those with a history of ulcers. Interpretation Individuals with diabetic neuropathy had increased intrinsic foot muscle deterioration, which was associated with second metatarsophalangeal joint angle and history of ulceration. Additional research is required to understand how foot muscle deterioration interacts with other impairments leading to forefoot deformity and skin breakdown.

Original languageEnglish
Pages (from-to)1055-1060
Number of pages6
JournalClinical Biomechanics
Volume28
Issue number9-10
DOIs
StatePublished - Nov 1 2013

Keywords

  • Foot deformity
  • Intermuscular adipose tissue
  • Muscle

Fingerprint Dive into the research topics of 'Intrinsic foot muscle deterioration is associated with metatarsophalangeal joint angle in people with diabetes and neuropathy'. Together they form a unique fingerprint.

Cite this